Özet:

Bacground and Aims: Spontaneous acid infection in patients with acidic cirrhosis is a complication with a high mortality rate. This study aimed to investigate the acid fluid and serum levels of proinflammatory cytokines interleukin-6 and tumor necrosis factor-alpha and acid fluid levels of nitric oxide and myeloperoxidase during spontaneous acid infection and to identify their diagnostic and predictive applicability with regard to acid cirrhosis. Materials and methods: We included 40 patients and categorized them into the following three groups: sterile acid, culture-negative neutrocytic acid, and spontaneous bacterial peritonitis. Acid fluid and serum samples were collected from patients upon admission and then stored. In all cases, acid fluid and serum levels of interleukin-6 and tumor necrosis factor-alpha were investigated by immunoradiometric method, acid fluid levels of myeloperoxidase by ELISA method, and nitric oxide levels by enzymatic method. Subsequently, these three groups were compared with each other. Results: Serum and acid fluid levels of interleukin-6 were significantly lower in the sterile acid group than in the culture-negative neutrocytic acid and spontaneous bacterial peritonitis groups. Serum interleukin-6 levels in the culture-negative neutrocytic acid and spontaneous bacterial peritonitis groups were significantly higher than those in the sterile acid group. Moreover, the acid fluid and serum tumor necrosis factor-alpha levels in the culture-negative neutrocytic acid group were significantly higher than those in the sterile acid group; however, there was no statistical difference in the intergroup serum tumor necrosis factor-alpha levels. The acid fluid levels of myeloperoxidase were also significantly higher in the sterile acid group than in the culture-negative neutrocytic acid group and spontaneous bacterial peritonitis group. We observed no significant intergroup differences with regard to the nitric oxide levels in acid fluid. Conclusion: In chronic liver parenchyma patients with neutrocytic acid cirrhosis, acid fluid and serum levels of interleukin-6 and acid fluid levels of myeloperoxidase may help the conventional methods in diagnosing spontaneous acid infection; however, the serum levels of nitric oxide and tumor necrosis factor-alpha have no diagnostic value. Key words: , , , , myeloperoxidase.

Anahtar Kelimeler: