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Amaç: Bu çalışmada metabolik olarak sağlıklı ve sağlıksız obez çocuklar arasında laboratuvar değerlerinin, özellikle serum ürik asit düzeyleri açısından bir fark olup olmadığı araştırılmıştır. Gereç ve Yöntemler: Obezite teşhisi konulan çocuk ve adolesan 220 kişinin verileri tıbbi kayıtlardan toplandı. Kardiyovasküler risk faktörleri (açlık serum lipidleri, kan basıncı ve açlık glukoz yüksekliği) olmayan obez bireyler sağlıklı obez (n = 124) olarak sınıflandırıldı. Bir veya daha fazla kardiyovasküler risk faktörü kriterini karşılayan kişiler sağlıksız obez (n = 96) olarak sınıflandırıldı. Kontrol grubu 111 sağlıklı bireyden oluşturuldu. Bulgular: Çalışmaya alınan olguların yaş ortalaması 12.14 ± 3.28 yıl, %44.4'ü (n = 147) erkekti. Obez bireyler ile sağlıklı kontroller arasında ürik asit düzeyleri arasında istatistiksel anlamlı olarak fark saptandı (sırasıyla, 308.11±71.97 umol/L (5.18±1.21 mg/dl), 251.6±70.78 umol/L (4.23±1.19 mg/dl) Z=6.670, p<0.001), bu fark metabolik olarak sağlıklı ve sağlıksız obezlerde saptanmadı (sırasıyla, 302.16±69 umol/L (5.08±1.16 mg/dl), 315.84±74.94 umol/L (5.31±1.26 mg/dl) Z=1.265, p=0.206). Ancak kilo, boy, vücut kitle indeksi, trigliserid, yüksek yoğunluklu lipoprotein ve insülin serum seviyeleri gibi ürik asit düzeyi üzerine etkili birçok faktör saptandı, fakat en güçlü oranda korelasyon vücut ağırlığı ile ürik asit düzeyi arasında saptandı (Spearman r=0.525, p <0,001). Ayrıca trombosit sayısı, ortalama trombosit hacmi ve trombosit dağılım genişliği açısından bu 3 grup arasında fark yoktu (sırasıyla H p, 3.620 0.164, 1.624 0.444 ve 1.948 0.378). Sonuç: Bu çalışma, obezlerde ürik asit düzeyinin sağlıklı kontrollere göre daha yüksek olduğunu, ürik asit düzeyleri ile en güçlü korelasyon gösteren parametrenin kilo olduğunu göstermektedir. Ancak ürik asit tek başına metabolik olarak sağlıklı ve sağlıksız obezlerde iyi bir gösterge değildir.
Purpose: This study has studied whether there is a difference in laboratory values between metabolically healthy and unhealthy obese children, especially in terms of serum uric acid levels. Tools and Methods: Data of 220 children and adolescents diagnosed with obesity were collected from medical records. Obesity individuals without cardiovascular risk factors (hungry serum lipids, blood pressure and hungry glucose levels) were classified as healthy obesity (n = 124). Persons who meet one or more cardiovascular risk factors were classified as unhealthy obesity (n = 96) The control group was formed from 111 healthy individuals. Results: The average age of the studies was 12.14 ± 3.28 years, with 44.4% (n = 147) men. The difference between obese individuals and healthy controls was statistically significant (secondly, 308.11±71.97 umol/L (5.18±1.21 mg/dl), 251.6±70.78 umol/L (4.23±1.19 mg/dl); Z=6.670, p<0.001), this difference was not metabolically found in healthy and unhealthy obesities (secondly, 302.16±69 umol/L (5.08±1.16 mg/dl), 315.84±74.94 umol/L (5.31±1.26 mg/dl); Z=1.265, p=0.206). However, many factors that influence uric acid levels, such as weight, size, body mass index, triglycerides, high-intensity lipoprotein and insulin serum levels, have been found, but a strong correlation has been found between body weight and uric acid levels (Spearman r=0.525, p <0,001). Furthermore, there was no difference between these 3 groups in terms of the number of thrombocytes, the average volume of thrombocytes and the width of the distribution of thrombocytes (respectively H; p, 3.620; 0.164, 1.624; 0.444 and 1.948; 0.378). Result: This study shows that the level of uric acid in obesity is higher than the healthy controls, the uric acid levels are the weight of the parameter that indicates an irregular correlation. But uric acid alone is not a good indicator of metabolically healthy and unhealthy obesity.
Aim: In this study it was investigated whether there is a difference between metabolically healthy (MHO) and unhealthy (MUO) obese children regarding laboratory results, especially serum uric acid levels. Patients and Methods: Data of 220 individuals diagnosed with obesity were collected from medical records. Obese individuals without cardiovascular risk factors (fasting serum lipids, blood pressure, and glucose) were classified as MHO (n=124). Individuals meeting one or more criteria of cardiovascular risk factors were classified as MUO (n=96). The control group was composed of 111 healthy individuals. Results: The mean age of the participants was 12.14±3.28 years, including 44.4% (n=147) were males. While there was statistical significance regarding uric acid between obese and healthy individuals (308.11±71.97 umol/L (5.18±1.21 mg/dl), 251.6±70.78 umol/L (4.23±1.19 mg/dl), Z=6.670, p<0.001, respectively). No statistical significance was found between MHO and MUO groups (302.16±69 umol/L (5.08±1.16 mg/dl), 315.84±74.94 umol/L (5.31±1.26 mg/dl), Z=1.265, p=0.206, respectively). However, uric acid had a significant correlation with many variables, such as weight, height, body mass index, triglyceride, high-density lipoprotein and serum insulin levels, but the strongest being with weight (Spearman r=0.525, p<0.001). Moreover, there was no difference between these 3 groups concerning platelet count, mean platelet volume, and platelet distribution width (H; p, 3.620; 0.164, 1.624; 0.444, and 1.948; 0.378, respectively). Conclusions: This study showed that uric acid level is higher in obese than healthy controls and the most significant correlation with weight. However, uric acid alone is not a good indicator between MHO and MUO groups.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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