Primer hiperparatiroidizm (pHPT) bir veya birden fazla paratiroid bezinden uygunsuz olarak otonom fazla paratiroid hormon (PTH) uretimine bagli olarak kalsiyum (Ca) metabolizmasinin regulasyonunda bozukluk sonucunda PTH ve Ca duzeylerinde artis veya bunlardan birinin (Ca, PTH) uygunsuz olarak normal olmasi ile karakterizedir. pHPT'nin %90-95'i ailesel oyku ve diger endokrin organ tumorleri ile iliskisi olmayan sporadik tip olup, %5-10'u herediterdir. pHPT'nin % 80-85'ine tek paratiroid adenomu, % 4-5'ine cift adenom, % 10- 15'ine coklu bez hiperplazisi ve % 1'den azina paratiroid kanseri neden olmaktadir. pHPT'nin tanisi biyokimyasal olarak koyulur. pHPT'nin tek kuratif tedavisi cerrahidir. pHPT'de ameliyat tercihi hastada herediter HPT olup olmamasina, cerrahi tedavi gerektirecek tiroid hastaligi olup olmamasina, yapilan preoperatif lokalizasyon calismalarina ve bu calismalardaki bulgulara gore, intraoperatif PTH kullanilma olanaklarina, cerrahin tercihine bagli olarak degisebilir. Mukemmel sonucu alabilmek icin preoperatif belirlenen cerrahi strateji, gerektiginde intraoperatif bulgulara gore revize edilebilir. pHPT'nin cerrahi tedavisinde 2 temel yaklasim, BBE ve MIP yontemleridir. BBE, pHPT'nin cerrahi tedavisinde mukemmel sonuclara sahip, altin standart olarak kabul edilen ve surekli gecerli bir opsiyon olmasina ragmen, gunumuzde MIP klinik ve radyolojik olarak tek bez hastaligi dusunulen secilmis hastalarda ideal yaklasimdir. Goruntulemenin negatif olmasi cerrahi endikasyonun olup olmadigini belirleyen kriter olmayip paratiroid cerrahisi icin kontrendikasyon degildir. Sporadik pHPT'nin cerrahi tedavisinde her iki yontem de guvenli ve etkili yontemler olmasina ragmen, her iki yontemin etkinligi ile ilgili tartismalar halen devam etmektedir. Temel olarak yapilan cerrahi girisim risk yarar dengesini iyi kurmali, persistan ve rekuren hastalik riskini minimalize ederek en yuksek kur oranini saglamali, komplikasyon riskini de arttirmamalidir. Kur oranini azaltan herhangi bir yontem persistan ve rekuren hastaliga bagli olarak ikincil paratiroidektomi riskini arttirmaktadir. Deneyimli cerrahlar tarafindan yapilan ikincil paratiroidektomilerde basari orani %90'in uzerinde olmasina ragmen, hastanin en dusuk komplikasyonla en yuksek kur orani ilk cerrahide elde edilebilir. Ayrica ikincil cerrahide komplikasyon oranlari daha yuksektir. Ikincil girisimlerde mumkun oldugunca goruntuleme klavuzlugunda selektif cerrahi uygulanmalidir. En az diseksiyonla ve en az morbidite ile en yuksek kurun saglanabilecegi cerrahi strateji belirlenmelidir. Bu calismada pHPT tanili hastalarda kime hangi cerrahi tedavinin uygulanabilecegini degerlendirmeyi amacladik.
Primary hyperparathyroidism (pHPT) is characterized by the disorder in the regulation of calcium (Ca) metabolism in the uretime of an autonomous overparathyroid hormone (PTH) from one or more parathyroid glands, due to the disorder in the PTH and Ca levels or the disorder of one of them (Ca, PTH) in an inappropriate manner. 90–95% of the pHPT is a sporty type that is not associated with family and large endocrine organs tumors, and 5–10% is hereditary. 80-85 percent of pHPT is caused by single parathyroid adenoma, 4-5 percent by cystic adenoma, 10-15 percent by cystic hyperplasia and 1 percent by azina parathyroid cancer. The pHPT is biochemical. The only curative treatment of pHPT is the surgeon. The preference for surgery in pHPT is that the patient does not have hereditary HPT, does not have thyroid disease that requires surgery, the preoperative localization calismalarina and the findings in these calismals can be overwhelmed by the possibilities of intraoperative PTH use, the preference of the surgeon. The preoperative strategy for the achievement of a stable result can be revised to intraoperative findings if necessary. In the surgical treatment of pHPT, 2 basic clusters are the BBE and MIP yontems. BBE is an option that has solid results in pHPT's surgical treatment, considered as the golden standard and is not a continuously effective option, ragmen is the ideal approach to MIP clinically and radiologically single-glass disease dusunulen secilmis patients. Not a criterion that determines whether or not the negative is a surgical indication and is not a contraindication for parathyroid surgery. In the surgical treatment of the sporadic pHPT, both yontems are guvenli and effective yontems, ragmen, the contests about the effectiveness of both yontems are still ongoing. Basically performed surgery should not increase the risk of complications by minimizing the risk of persistent and recurrent disease, and should not increase the risk of complications. Any yontem that reduces the cur rate persists and increases the risk of secondary parathyroidectomy due to recurrent disease. In secondary parathyroidectomies performed by experienced surgeons, the basary rate of 90 per cent is not extended, ragmen can be obtained in the first surgeon with the patient's worst complication. In secondary surgery, the rate of complications is higher. When the second inputs are candlesticked, selectively surgery should be applied in the goruntulating keyboard. With a minimum of disection and a minimum of morbidity, the highest moisture can be stretched, the surgical strategy should be determined. In this calcium, we intended to determine which surgery therapy can be applied to those with pHPT.
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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