Özet:

Purpose: The aim of this study is to compare the smelling functions of patients with active acromegaly with patients in the biochemical remission. Methods and tools: The study was carried out by forming 2 groups of patients diagnosed with acromegaly and a control group. The group 1 was composed of active acromegaly patients. The group 2 included patients identified with biochemical remission. The group was composed of three healthy volunteers. The function of smelling was assessed by the Brief Smell Identification Test (BSIT). A total of 69 patients were included in the study. The average value of blood insulin-like growth factor 1 (IGF-1) in Group 1 was statistically significantly higher than in Group 2 (p <0,001). There was a significant difference between the groups in terms of the BSIT scores (p <0,001). BSIT scores in Group 1 were found to be significantly lower than both Group 2 and Group 3 (p = 0,001). There was no significant difference between Group 2 and Group 3 (p = 1000). Furthermore, a negative correlation between the BSIT scores and the IGF-1 values was determined (r = -0.983, p <0.001), (r = -0.629, p <0.01). The result: there is a reduction in the smelling functions of the active acromegalytic patients according to the biochemical remission, and this function loss shows a negative correlation with the levels of IGF-1.

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