Özet:

Essential hypertension is a polygenic disease indicating that several genes are involved in its pathogenesis. The renin-angiotensin  system, which is involved in the regulation of blood pressure, may play an important role in the development of hypertension. It is shown taht the angiotensinogen (AGT) gene had genetic polymorphism and and most common variants of AGT are T174M and M235T. In several studies on varies populations, it was observed that M235T variant is more related witch essential hypertension than other variants. However, the relation between AGT gene polymorphism and hypertension shows ethnic differences. We examined 105 hypertensive patients and 56 normotensive persons to estimate allel frequency of AGT 235T variant and to establish relationship with essential hypertension in Turkish population. In this study, orginally, mutagenically seperated  (MS) PCR  was used in the from of touch down (TD) PCR. Frequency of 235T allel was found 0.43, which accords to previous studies results in whites. Several studies were shown differences about their relation with essential hypertension. In our study we have not observed any significant relationship between the variant of AGT 235T and essential hypertension (P=0.54). However, we observed that hypertensive patients with homozygous T genotype have higher systolic blood pressure than hypertensive patients with other genotype (TM+MM,  p<0.02).

Anahtar Kelimeler: