Abstract:

Abstract: Bacground and Aims. Alkaline reflux gastritis is characterized by non-acidic flow from the duodenum to the stomach. It is seen very commonly among operated patients. It can also be seen among non-operated patients, due to a defect in duodenogastric antireflux mechanisms. Various medications are used for its treatment. We aimed to analyze the clinical, endoscopic, and histological effects of ursodeoxycholic acid in non-operated patients in this study. Material and Methods. A total of 72 patients who were diagnosed with alkaline reflux gastritis as a result of endoscopic imagining were treated with ursodeoxycholic acid. Clinical, endoscopic, and histological features were analyzed after 2 months of treatment. A total of 72 patients were analyzed clinically, and 61 patients who had control endoscopy were analyzed endoscopically and histologically. Results. Of the total, 38 patients were female and 34 were male. The youngest and oldest patients were 19 and 81 years of age, respectively. The average age was 50 years. After treatment, 54 patients out of 72 reported benefits. Sixteen patients out of 61 who had control endoscopy were diagnosed endoscopically with alkaline reflux gastritis. Normal mucosa was observed instead of chronic gastritis and inflammation in 6 out of 61 patients who had control histological examination. Conclusion. In all, 75% of the patients who were treated with ursodeoxycholic acid recovered clinically. Altogether, 73.7% of patients recovered endoscopically. Only 9.9% of patients recovered histologically. In conclusion, ursodeoxycholic acid treatment is effective clinically and endoscopically but is ineffective histologically.

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