Abstract:

ate aqueous extract of Geniosporum prostratum (L) Beanth in normal and streptozotocin (STZ) induced diabetic rats. Diabetes was induced by intraperitoneally (i.p) streptozotocin (60mg/kg)adult male albino wister rats (8 weeks), weighing 200 to 250 g. Blood glucose levels were determined after oral administration of G. Prostratum (200 mg/kg) in diabetic groups. At the end of 21 daysafter daily oraladministration of aqueous extract of G. Prostratum(100 &200 mg/kg) and standard drug (600 μg/kg) in diabetic rats, rats were autopsized and liver was removed. The effect of extracts of G. Prostratumon antioxidant like catalase, superoxide dismutase, lipid peroxidase and glutathione were estimated in the diabetic and non-diabetic rats. There was significant increase in catalase, superoxide dismutase, liver peroxidase and glutathione in extracts treated diabetic rats. These results indicate that G. Prostratumreduce anoxidative stress in diabetic rats.

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