Özet:

Amiodarone is a currently used drug with high efficacy for the treatment acute life-threatening arrhythmias. Although the use of this drug is widespread, it is associated with unwanted systemic effects. S-methylmethionine sulphonium, which is a derivative of the methionine amino acid, defined mostly as vitamin U and various beneficial effects of Vit U have been demonstrated. The present study was planned to determine whether the vitamin U exhibits preventive effects on amiodarone-induced liver toxicity. Male Sprague-Dawley rats were randomly divided into four groups. Group I; control animals receiving corn oil. Group II; control animals receiving Vit U (50 mg/kg) for 7 days orally. Group III; animals receiving 100 mg/kg amiodarone for 7 days orally. Group IV; animals receiving Vit U orally for 7 days (in the same dose and time) 1 h prior to the administration of amiodarone. Pretreatment with vitamin U particularly decreased degenerative morphological changes such as picnotic nucleus in hepatocytes, sinusoidal dilatation, hyperemia seen in amiodarone treated individuals. On the other hand liver aspartate transaminase, alanine transaminase and alkaline phosphatase activities were increased, catalase, superoxide dismutase, glutathione peroxidase, glutathione-S-transferase activities were decreased in amiodarone group. Administration of vitamin U reversed these effects in amiodarone group. In conclusion, it might be suggested that pretreatment with vitamin U have protective effects on liver injury induced with amiodarone through decreasing oxidative stress. 

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