Özet:

Phyllanthus niruri is herbal plants having potential medicinal remedial properties to cure many disease and metabolic disorders. Here, we study the in vivo acute toxicity and hypoglycemic effect of whole phytochemical extract of P niruri different varieties collected from Northern Uttar Pradesh and Uttarakhand region and their phytochemicals ethanolic extract collected for the in vivo study in mice model. Plant extracts enriched with different type biochemical, amino acids, saponins, tannins, flavonoids were administrated in mice model in different concentration to check the acute toxicity. Subsequently, hypoglycemic effect of the plant extract was studied in Streptozotocin (STZ) induced induce hyperglycemia or diabetic mice contrary to control and standard drug group i.e., glibenclamide. Results showed that doses upto 1000 mg/kg body weight has lethal effect on animals. However, the aqueous extract increases upto 400mg/kg body weight significantly reduces the blood glucose level in hyperglycemic mice and shown that each sample has positive hypoglycemic efficiency.

Anahtar Kelimeler: