Abstract:

Purpose: Civan perchemy (CP) has antioxidant, antibacterial, diuretic and anti-inflammatory effects. In our study, we studied the protective effect of CP on the MDA level and antioxidant enzyme activity in the muscle tissues created by diabetes with streptosotine. Tools and methods: 250-300 gr 40 male Wistar albino rats were used in the study. The control group was divided into 3 groups, including the Diabetes group and the Diabetes group treated with CP. A single dose of 60 mg/kg of streptozocin (STZ) was injected intraperitoneally to cause diabetes in rats. The treatment group was given CP 250 mg/kg/day for a period of 6 weeks. At the end of the trial, all the animals were sacrificed. The findings: The study found that when compared to the control group in streptozocin and diabetes-generated rats, diabetes-generated rats observed statistically significant differences in the lipite peroxidation product (MDA) in the liver tissue and in the SOD enzyme activity, CAT and GSH levels (by p<0.001. However, 6 weeks after CP treatment in diabetic rats, a statistically significant decrease in tissue MDA levels was observed, while a significant increase in GST and CAT enzyme activity was observed (with p<0.001 sequence). The result: in diabetes, the stimulation of oxidative stress is considered important. This study shows that CP can have protective effects against lipid peroxidation in the case of diabetes because it causes an increase in antioxidant enzyme activities.

Keywords: