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Amaç:Sistemik inflamasyonun kanser gelişiminde önemli bir risk faktörü olduğu uzun zamandır bilinmektedir. Kolorektal kanser (CRC) de dünyada kanser ilişkili morbidite ve mortalitenin en sık nedenlerinden biridir. Bu çalışmada CRC’li hastalarda tanı anından bakılan sistemik immün-inflamasyon indeksi (SII) ve panimmun inflamasyon değeri (PIV) gibi inflamatuar parametrelerin sağlıklı kontrol grubu ile karşılaştırmayı amaçladık. Gereç ve Yöntemler:2012-2016 yılları arasında dahiliye kliniğinde CRC tanısı alan 162 hastanın verileri retrospektif olarak incelendi ve dahil edilme kriterlerini sağlayan toplam 139 hasta çalışmaya dahil edildi. Tüm hastaların tanı anında bakılan hemogram değerleri, histopatolojisi ve TNM sınıflamasına göre tümör evreleri kaydedildi. Hastaların nötrofil-lenfosit oranı (NLR), platelet-lenfosit oranı (PLR), lenfosit-monosit oranı (LMR), SII ve PIV, nötrofiller, monositler, trombositler ve lenfositler gibi hemogram parametreleri kullanılarak hesaplandı. Bulgular: Çalışmaya 139 CRC’li hasta ile yaş ve cinsiyet dağılımı benzer olan 139 sağlıklı kontrol grubu dahil edildi. Çalışmaya dahil edilen tüm vakaların yaş ortalaması 61.7±11.8 olup 170’i erkek (%61.2) idi. CRC grubunda SII, PIV, NLR ve PLR düzeyleri kontrol grubuna göre anlamlı yüksek, LMR düzeyi anlamlı düşüktü ( sırası ile p< 0.001 p< 0.001 p< 0.001 p< 0.001p= 0.001). CRC grubu hastalık evresine göre ayrıldığında tüm evrelerin kontrol grubuna göre SII ve PIV düzeyleri anlamlı yüksekti (SII için p= 0.029 p< 0.001 p= 0.001 p= 0.002 PIV için p= 0.034 p< 0.001 p= 0.002 p= 0.014) Sonuç: Erken tanısı büyük önem taşıyan CRC’li hastalarda kolonoskopik taramanın yanında, ek bir maliyet gerektirmeyen, rutin hemogram testi ile ölçülebilen SII ve PIV değerleri de dikkate alınabilir.
It has long been known that systemic inflammation is an important risk factor in the development of cancer. Colorectal cancer (CRC) is one of the most common causes of cancer-related morbidity and mortality in the world. In this study, we aimed to compare diagnosed in patients with CRC with a healthy control group of inflammatory parameters such as the systemic immune inflammatory index (SII) and the panimune inflammatory value (PIV). The data of 162 patients diagnosed with CRC in the intrusion clinic between 2012 and 2016 were retrospective and a total of 139 patients provided the inclusion criteria were included in the study. The tumor stages were recorded according to the hemogram values, histopathology and TNM classification of all patients diagnosed immediately. Patients' neutrophil-lenfocytes rate (NLR), platelet-lenfocytes rate (PLR), lymphocytes-monocytes rate (LMR), SII and PIV, neutrophiles, monocytes, thrombocytes and lymphocytes were calculated using hemogram parameters. Results: The study included 139 healthy control groups, with 139 patients with CRC, similar to age and gender distribution. The average age of all cases included in the study was 61.7±11.8 and 170 were male (61.2%). The levels of SII, PIV, NLR and PLR in the CRC group were significantly high compared to the control group, the level of LMR was significantly lower (relevantly p< 0.001 p< 0.001 p< 0.001 p< 0.001 p< 0.001p= 0.001). When the CRC group was divided according to the stage of disease, the levels of SII and PIV were significantly higher according to the control group of all stages (p= 0.029 p< 0.001 p= 0.001 p= 0.002 PIV p= 0.034 p< 0.001 p= 0. 002 p= 0.014) Result: In addition to colonoscopic screening in patients with CRC with early diagnosis of great importance, SII and PIV values, which can be measured by routine hemogram tests, which do not require any additional cost, can also be considered.
Aim: It has been known for a long time that systemic inflammation is an important risk factor in cancer development. Colorectal cancer (CRC) is one of the most common causes of cancer-related morbidity and mortality in the world. In this study, we aimed to compare the inflammatory parameters tested in CRC patients at the time of diagnosis such as systemic immune-inflammation index (SII) and pan-immune inflammation value (PIV) with those of the healthy control group. Materials and Methods: The data of 162 patients diagnosed with CRC in the internal medicine clinic between 2012-2016 were analysed retrospectively and a total of 139 patients who met the inclusion criteria were included in the study. Hemogram values, histopathology and tumour stage according to TNM classification of all patients at the time of diagnosis were recorded. The patients’ neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), SII and PIV were calculated using hemogram parameters such as neutrophils, monocytes, platelets and lymphocytes. Results: A total of 139 CRC patients and 139 healthy control subjects with similar age and sex distribution were included in the study. The mean age of all subjects included in the study was 61.7±11.8 years, and 170 subjects (61.2%) were male. In the CRC group, SII, PIV, NLR, and PLR levels were significantly higher, and LMR level was significantly lower than the control group (p<0.001, p<0.001, p<0.001, p<0.001, p=0.001, respectively). When the CRC group was divided according to the disease stage, it was found that SII and PIV levels of all stages were significantly higher than the control group (p= 0.029, p<0.001, p= 0.001, p= 0.002 for SII, p= 0.034, p<0.001, p= 0.002, p= 0.014 for PIV). Conclusion: In addition to colonoscopy screening in patients with CRC, whose early diagnosis is very important, SII and PIV values that do not require an additional cost and can be measured in routine hemogram tests can also be taken into consideration.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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