Abstract:

Purpose: Studies have shown that alcoholic toxic effects on the central nervous system (MSS). The increase in the production of free oxygen radicals (SOR) in the pathogenesis of the toxic effect of alcohol on the MSS is held responsible for the suppression of the production of endogenous antioxidants. Our goal is to research the biochemical effect of Taxifolin on ethanol-induced oxidative brain damage in rats. Tools and Methods: The experimental animals were divided into healthy (SG), solitary ethanol field control (EtOH) and taxifoline + ethanol (TEtOH) given groups. At the end of the given time, ethanol and taksipholin were removed from brain tissues by killing animals with high doses of anesthesia. In the extracted brain tissues, total glutation (tGSH), which is the product of lipid peroxidation (MDA) and endogenous antioxidant (tGSH), was measured. Results: In the ethanol given animal group, the amount of MDA was found healthy and significantly high (p<0.001) and tGSH significantly low (p<0.001) compared to the taxifoline group. Results: Our findings indicate that taxifoline protects the brain tissue against the oxidative damage of ethanol.

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