Özet:

Objectives: In ambulatory blood pressure monitoring trials, non-dipper hypertensive patients had a worse cardiovascular outcome than dipper hypertension (HT) patients. However, no trials have been performed to inquire into the relationship between ambulatory blood pressure variability and coronary artery disease. In large-scale research, the atherogenic index of plasma has been found as a marker of coronary artery disease. This study inquired if there was a correlation between blood pressure variability and the atherogenic index of plasma. Materials and Methods: The study involved 158 hypertensive patients. Patients were distributed as non-dipper HT and dipper HT according to 24-hour ambulatory blood pressure follow-up. The dipper HT group consisted of 49 individuals, while the non-dipper HT group consisted of 109 patients. Biochemistry, hemogram and echocardiographic were examined. Results: Gender, previous diagnosis of HT, serum creatinine, hemoglobin and cholesterol, triglyceride levels were similar in both groups. The dipper HT group had more patients with diabetes (36.7% vs 13.8% p<0.001). The median age of the participants was statistically significantly higher in the non-dipper HT group [44 (22) vs. 50.5 (17.3) p=0.022]. High inflammatory markers were similar in both groups, but the atherogenic index of plasma in the dipper HT group was significantly higher than the non-dipper HT group (0.250±0.262 vs 0.141±0.262 p=0.017). In the echocardiographic comparison, the ejection fraction, relative wall thickness and left atrial diameters were similar in both groups, whereas the non-dipper HT group had a considerably larger ascending aortic diameter. Conclusion: The atherogenic index of plasma, which is an important predictor of coronary artery disease, was found to be higher in the dipper HT group. This is the first study to inquire into the correlation between the atherogenic index of plasma and ambulatory blood pressure change.

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