Objectives: Psoriasis is a chronic inflammatory, immune-mediated disease, and platelets have an important role in the pathomechanisms of psoriasis. Recent studies showed that MPV (mean platelet volume) could be used as a marker of platelet activation. In this study, we aimed to investigate the MPV level and platelet count in psoriasis patients and its association with disease severity. Methods: We designed a case-control study with 28 psoriasis patients and age and sex-matched 30 healthy controls. Haematologic parameters and sedimentation rates compared between groups. These parameters also correlated with PASI (Psoriasis Area and Severity Index) score. Results: MPV and platelet count were significantly higher in patients with psoriasis than controls (p=0.012, p=0.015). Also, platelet count was showed positive correlation with PASI scores (r=0.424, p=0.025). The sedimentation rate was not statistically different between groups. Conclusion: There are many conflicting results about the correlation of haematologic parameters and psoriasis. We found that MPV and platelet counts higher in the psoriasis group, which suggests that platelets play an important role in the pathomechanism of psoriasis and may be helpful in assessing treatment outcomes.
Purpose: Psoriasis is a chronic, inflammatory, immune-transmitted skin disease and it is known that the thrombocytes play a role in pathophysology. In recent studies, MPV (mediate volume of thrombocytes) is considered a indicator of thrombocytes activation. In our study, we aimed at comparing the MPV and thrombocytes levels of psoriasis patients with the healthy control group and correlating it with the severity of the disease. Tools and Methods(s): We designed a case-control study involving twenty-eight psoriasis and 30 healthy control patients matched by age and gender. We compared the hematological parameters in both groups, measuring the speed of sedimentation between the groups, and we also assessed the correlation of these values with the score in the group of patients (Psoriasis Field Violence Index). The statistical analysis was done using SPSS (Version 15.0). Spearmen Correlation Analysis has been used for the relationship between PAXI and other parameters. Results: The number of MPVs and thrombocytes was statistically significantly increased compared to healthy controls in the psoriasis group (p=0,012, p=0,015). It also found a statistically meaningful relationship between the trombocytes and the PASI scores in a positive direction (r=0,424, p=0,025). The speed of sedimentation was not different between the groups. Result(s): The results of studies aimed at revealing the relationship between psoriasis and hematological parameters
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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