Abstract:

Purpose: Psoriasis is a chronic, inflammatory, immune-transmitted skin disease and it is known that the thrombocytes play a role in pathophysology. In recent studies, MPV (mediate volume of thrombocytes) is considered a indicator of thrombocytes activation. In our study, we aimed at comparing the MPV and thrombocytes levels of psoriasis patients with the healthy control group and correlating it with the severity of the disease. Tools and Methods(s): We designed a case-control study involving twenty-eight psoriasis and 30 healthy control patients matched by age and gender. We compared the hematological parameters in both groups, measuring the speed of sedimentation between the groups, and we also assessed the correlation of these values with the score in the group of patients (Psoriasis Field Violence Index). The statistical analysis was done using SPSS (Version 15.0). Spearmen Correlation Analysis has been used for the relationship between PAXI and other parameters. Results: The number of MPVs and thrombocytes was statistically significantly increased compared to healthy controls in the psoriasis group (p=0,012, p=0,015). It also found a statistically meaningful relationship between the trombocytes and the PASI scores in a positive direction (r=0,424, p=0,025). The speed of sedimentation was not different between the groups. Result(s): The results of studies aimed at revealing the relationship between psoriasis and hematological parameters in the literature are contradictory. We have high levels of MPV and thrombocytes in patients with psoriasis and our results are qualified to support the role of thrombocytes in psoriasis pathogenesis and can be used in the follow-up of therapeutic results in the future.

Keywords: