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Giriş: Enflamasyon, koroner arter hastalıklarının temelinde ve olumsuz sonlanımlarında önemli rol oynar. Nötrofil-lenfosit oranı (NLR), sistemik immün inflamasyon indeksi (SII) ve CRP ise inflamatuar durumu yansıtan basit ve kullanışlı belirteçlerdir. Çalışmamızın amacı bu belirteçlerin koroner arter hastalığı tanılı COVID-19 hastalarında hastane içi mortaliteyi öngörmede kullanılabilirliğini değerlendirmeyi amaçladık. Gereç ve Yöntem: Çalışmamız 111 (48 erkek, 63 kadın) yeni tanı COVID-19 hastasından oluşuyordu. Nötrofil (N), lenfosit (L) değerleri kullanılarak NLR (N/L) ve N,L ve trombosit (P) değerleri kullanılarak sistemik immün inflamasyon indeksi SII (NxP / L) elde edildi. NLR, SII ve CRP değerlerinin hastane içi mortaliteyle olan ilişkileri incelendi. Bulgular: Tedavi sürecinde 16 hastada ölüm izlendi. N, L ve P değerleri hayatını kaybenler ve şifa ile taburcu olan grup arasında kıyaslandığında istatiksel farklılıklar izlenmedi ( p= 0.971, p=0.256, p=0.759 sırasıyla). Bunların kombinasyonu ile elde edilen SII ve NLR değerleri içinde gruplar arasında istatiksel farklılıklar izlenmezken (p=0.872, p=0.979 sırasıyla), CRP değerlerinde ise hastane içi ölüm izlenen grupta istatiksel anlamlıydı (p<0.001). Logistik regresyon analizinde, CRP’nin (odds oranı [OO]= 1.078 ,%95 güven aralığı [GA]: 1.0225-1.133, p= 0.003) hastane içi mortaliteyle ilşkili olduğu gösterildi. ROC analizinde hastane içi mortaliteyi tahmin etmede CRP için 3.1 mg/dL kestirim değerleri %87 hassasiyet ve %58 özgüllük ile anlamlı bulundu (p<0.001). Sonuç: Koroner girişim öyküsü olan koroner arter hastalığı tanılı COVID-19 hastalarında CRP seviyeleri hastane içi ölümle ilişkilidir.
Introduction: Inflammation plays an important role in the basis of coronary arterial diseases and in the negative outcomes. The neutrophil-lenphocytes rate (NLR), the systemic immune inflammation index (SII) and the CRP are simple and useful indicators that reflect the inflammatory condition. The aim of our study is to evaluate the availability of these indicators in the prediction of hospital mortality in COVID-19 patients known for coronary artery disease. Our study consisted of 111 (48 men, 63 women) new diagnosis of COVID-19 patients. The systemic immune inflammation index SII (NxP / L) was obtained using the NTR (N/L) and N,L and thrombocytes (P) values using the NTR (N), lymphocytes (L) values. The relationship between NLR, SII and CRP values with hospital mortality was studied. In the course of the treatment, 16 patients died. No statistical differences were observed when the values of N, L and P were compared to those who lost their lives and healed and dispersed (p=0.971, p=0.256, p=0.759 respectively). The SII and NLR values obtained by their combination were not statistical differences between the groups (p=0.872, p=0.979 respectively), while the CRP values were statistically meaningful in the patient death group (p<0.001). In logistic regression analysis, it was shown that CRP (odds ratio [OO]= 1.078 , 95% confidence range [GA]: 1.0225-1.133, p= 0.003) was associated with hospital mortality. In the ROC analysis for the prediction of hospital mortality, the cutting values of 3.1 mg/dL for CRP were found meaningful with 87% sensitivity and 58% specificity (p<0.001). The result: CRP levels in COVID-19 patients with chronic arterial disease, which is a coronary initiative history, are associated with hospital death.
Introduction: Inflammation plays an important role in the basis of coronary artery diseases and their adverse outcomes. Neutrophil-lymphocyte ratio (NLR), Systemic Immune Inflammation Index (SII) and C-reactive protein (CRP) are simple and useful markers that reflect the inflammatory state. Our study evaluated the usability of these markers in predicting in-hospital mortality in patients with COVID-19 with the diagnosis of coronary artery disease. Material and Method: Our study population consisted of 111 (48 male, 63 female) newly diagnosed patients with COVID-19. Neutrophil-lymphocyte ratio (NLR) was estimated using neutrophil (N), and lymphocyte (L) counts and the systemic immune inflammation index SII (NxP / L) was calculated using N, L and platelet (P) values. The relationship of NLR, SII and CRP values with in-hospital mortality was investigated. Results: During the treatment process, 16 patients exited. Any statistically significant intergroup difference was not observed as for SII and NLR values obtained by their use in combination (p = 0.872, p = 0.979, respectively), CRP values were statistically significant in the group with in-hospital mortality (p <0.001). In logistic regression analysis, CRP (odds ratio [OR] = 1.078, 95% confidence interval [CI]: 1.0225-1.133, p = 0.003) was associated with in-hospital mortality. In ROC analysis, the cut-off values of 3.1 mg / dL, for CRP were significant with 87% sensitivity and 58% specificity in predicting in-hospital mortality (p <0.001). Conclusions: CRP levels are associated with in-hospital mortality in patients with COVID-19 who had also received coronary artery disease with a history of coronary intervention.
Field : Sağlık Bilimleri
Journal Type : Uluslararası
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