Özet:

In recent years, with the acceleration of drug reposition studies, farmacokinetic and optimal doses well-known drugs, which have been harmless, are subjected to re-research for use in different indications. There is no clinically proven therapy or vaccine against SARS-CoV-2 that causes pandemic today. In the treatment of COVID-19 disease, the treatment potential of chlorokin and hydroxyclorokin has been greatly highlighted. This collection examines the existing data on the pharmacokinetics, pharmacodynamic properties, use and safety of chlorokin/hydroxychlorokine, an ancient drug that has been re-established with the treatment of COVID-19, and provides data on the effectiveness and safety of SARS-CoV-2 infection according to current research in the literature. As Chlorokin/Hydroxychlorokin ranked first in the treatment algorithms of COVID-19 disease, more randomized controlled clinical trials are also needed.

Anahtar Kelimeler:

Özet:

Drugs that have been proven to be significantly harmless, and whose pharmacokinetics and optimal dosage are well known are subject to re-research for new indications since drug repositioning studies have been accelerated. Today, clinically proven treatment or vaccine has yet to be established against SARS-CoV-2, which caused the pandemic. In the treatment of COVID-19 disease, the treatment potential of chloroquine and hydroxychloroquine has drawn considerable attention. In this review, pharmacokinetic and pharmacodynamic properties, the information about use and safety in special populations, and particularly data on efficacy and safety in SARS-CoV-2 infection regarding recent studies of chloroquine/hydroxychloroquine, an old drug that is currently used in the treatment of COVID-19 is presented. Although chloroquine / hydroxychloroquine ranks first in the treatment algorithms of COVID-19 disease, more randomized controlled clinical trials are also required.