Özet:

A protein synthesis inhibitor, clindamine is an anti-microbial agent that is bacteriostatically effective and has previously demonstrated neuroprotective effect in the ischemic brain tissue in rats. In this study, we aimed at assessing the neuroprotective effectiveness of clindamine on the spinal cord. Tools and Methods: 20 Wistar Albino rates weighing 200-300g were used for the study. Ratlar Sham group (5 rat) group 1, trauma group (5 rat) group 2, carrier group (5 rat) group 3, and therapeutic group (5 rat) group 4 will be divided into 4 groups. In groups outside the Sham group, aort from the left renal artery with laparotomy was clamped for 45 minutes. 1 cc serum in the carrier group and 20 mg/kg in the therapeutic group was administered by clindamisin intraperitoneal. The rats were sacrificed after 24 hours. MDA levels were studied in all tissues by removing the spinal cords after laminectomy between T8-12. Results: A statistically significant difference was observed between the Sham group and the other groups in terms of 1.hour motor scores (p=0,008). Again, the difference between the sham group and the trauma and the carrier group was statistically meaningful (p=0,008) at 24 hours, but the difference between the trauma group and the therapeutic group was statistically meaningful (p=0,151). When compared the MDA levels of groups using Kruskal Wallis variance analysis, the result was statistically meaningful (p=0,035). However, when compared using Mann Whitney U test, there was no meaningful difference between the treatment group and the trauma and the carrier groups. The result: In this study, clindamine was found that in the prevention of spinal ischemic reperfusion damage, it did not have sufficient effectiveness in the dose and time we gave. Keywords: clindamine, clindamine, clindamine, clindamine ABSTRACT Objective: Clindamycin, a protein synthesis inhibitor, is an antimicrobial agent with bacteriostatic effect and previously proven neuroprotective activity in ischemic brain tissue in rats. We aimed to evaluate the neuroprotective effectiveness of clindamycin on the spinal cord. Material and Methods: For the study 20 Wistar Albino rats. Rats were divided into 4 groups. Sham group; group1, the trauma group; group 2, control group; group 3, and treatment group; group 4. We put a clip to the aorta under the left renal artery for 45 minutes after laparotomy except the sham group. 1 cc saline 20 mg/kg clindamycin was administered intraperitoneally to control group and treatment group. Results: The difference first hour of engine scores between the Sham group and the others was statistically significant. The hour difference between sham and trauma, and control groups was statistically significant. However, the difference between the trauma group and the treatment group was not statistically significant. MDA levels of groups were compared using Kruskal Wallis analysis of variance results were statistically significant. But then using Mann Whitney U test when comparing treatment groups with the trauma and the difference between the control group was not statistically significant. Conclusion: Ischemic and traumatic injury which were made in the spinal cord in animal studies show that the clindamycin is not effective on lipid peroxidation and free radicals also it does not have a neuroprotective activity on the spinal cord. Keywords: Spinal Cord; Clindamycin; Ischemia.

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