Abstract:

Purpose: In this study, we aimed at evaluating the changes that occur in the retinal microvascular structure in obese patients and determining the relationship of these changes with clinical characteristics. Tools and Methods: All participants conducted biochemical examinations containing cholesterol, hunger blood sugar, hunger insulin, CRP and HbA1C levels. The plasma aterogenic index (AI) was calculated as the logaritm of the ratio of plasma triglyceride (TG) levels to high-intensity lipoprotein (HDL) levels [log (TG/HDL-K)]. Patients with body mass index (BMI) ≤25 kg/m2 were included in the control group. Obesity patients were divided into three groups according to VKI: group 1 (VKI: 30-34.99 kg/m2), group 2 (VKI: 35-39.99 kg/m2) and group 3 (VKI ≥ 40 kg/m2) . Optical coherence tomography anjiography (OKT-A) with the foveal avascular zone (FAZ), the surface and deep capillary plexus vascular dancity (VD) with the radial peripapillary capillary plexus VD was measured. The study included a total of 110 patients, including 27 controls and 83 obese patients. In comparison with control cases, the levels of HbA1C, hunger insulin, HOMA-IR, C-reactive protein and AI were significantly high in obese patients. In obese patients, the surface (p=0,003) and deep (p=0,001)VDs of the retina significantly decreased and the FAZ significantly increased (p=0,032). In the analysis of the correlation between clinical characteristics and OKT-A findings, surface and deep VDs were reverse proportions to age, VKI, HbA1C and AI. Result: In obese patients, the surface and deep VDs of the retina were reduced and there was a reverse relationship between retinal VDs and age, VKI, HbA1C and AI.

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