Fluvoxamine is an antidepressant drug belonging to the class serotonin re uptake inhibitor(SRI),exhibits maximum absorption through the oral route of administration. The objective of current research is to formulate mouth dissolving fluvoxamine films by employing super disintegrants. The central composite design employed to examine the effects of amount of hydroxyl propyl methylcellulose (HPMC) E15, eudragitRL100 and polyethyleneglycol (PEG4000) on response variables such as tensile strength, disintegration time and cumulative% drug release. Fluvoxamine mouth dissolving films are formulated by using solvent-casting method using HPMCE15, EudragitRL100, and PEG4000. CCD is employed to optimize the effective dosage of formulation super disintegrants. 27 formulations were prepared according to CCD and evaluated for physic-chemical parameters and invitro dissolution studies. The formulation FF15 were observed with a maximum tensile strength of 55.63±1.37mg, least disintegration time of 29±1.85 seconds, and highest drug release of 98.29±1.87% and is chosen as an optimal formulation with maximum content uniformity and folding endurance. It is evident from the above results that the developed formulation can be an innovative dosage form to improve the drug delivery, quick on set of action, as well as, improve patient compliance in the effective management of depression.
Alan : Fen Bilimleri ve Matematik; Sağlık Bilimleri
Dergi Türü : Uluslararası
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