Özet:

INTRODUCTION: The aim of the study was to investigate the electrochemical behavior of rifampicin in the anodic direction using multiwalled carbon nanotube modified glassy carbon electrodes. METHODS: The anodic investigation of rifampicin was carried out with cyclic, differential pulse and square wave voltammetry techniques. The three-electrode system consisting of a glassy carbon electrode with a modification of MWCNT as working electrode, a platinum wire as counter electrode, and an Ag/AgCl electrode as reference was used for the experiments. RESULTS: The anodic process of rifampicin was irreversible and diffusion controlled. Linear responses were obtained between 0.04 and 10 μM for both techniques in acetate buffer at pH 3.5 as supporting electrolyte. Limit of detection values were 7.51 and 11.3 nM for differential pulse and square wave voltammetry techniques, respectively. The repeatability, reproducibility, precision, and accuracy of the proposed methods were also investigated. Determination of rifampicin was carried out from its pharmaceutical dosage forms and the results were compared with other electrochemical sensors and also the liquid chromatographic and spectrophotometric methods in the literature. DISCUSSION AND CONCLUSION: These validated techniques provided selective, rapid, sensitive, precise, and cheap determination of rifampicin as alternative techniques to the liquid chromatographic and spectrophotometric methods in therapeutic drug monitoring.

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