Abstract:

Abstract For the multi-component one-pot synthesis of dihydropyrimidinone, a hydrotalcites (HT) catalyst was used. Nitrogen-containing heterocycles are the most essential compounds in medicinal chemistry, as they exhibit a broad range of biological activities. The current study focuses on the environmentally favorable synthesis of 3,4-dihydropyrimidine-2(1H)-thione (DHPMT) in the presence of different hydrotalcite catalysts under mild conditions. Thus, prepared compounds are analysed by InfraRed spectroscopy (IR), 1H NMR and 13C NMR Spectroscopy. When the compounds were tested for antibacterial activity, compound 2 performed well when compared to the normal. Higher yields, shorter reaction times, and a quicker set-up are all advantages of this green synthetic form. The easy reusability of biocompatible catalysts makes this protocol is an attractive, cost-effective and eco-friendly.

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