Abstract:

The aim of this study is to investigate the effect of ketamine and thiopental used in sezaryan anaesthesia and postoperativ analgesic requirement. 40 patients who underwent cesarean section were enrolled into study. Patients were instructed on the use of a 100 -mm visuel analog skala (VAS) for the measurement of pain and patient-contrelled analgesia (PCA). Induction was achieved by thiopental 5 mg/kg in group T (n=20) and by ketamine 1 mg/kg in group K (n=20). Muscle relaxation was performed by rocuronium 0.6 mg/kg. Anaesthesia was maintained with 50 % nitrous oxide in oxygen till the fetus was delivered. After delivery of fetus, fentanyl 0.001 mg/kg was given and isofluran 0.8 % was added. The time in which patients were able to respond commands was recorded in postoperative period. The PCA device was set to deliver a bolus of tramadol 50 mg, with lock-out interval of 15 min and 4 h maximal dose of 200 mg. Sedation score, VAS, cumulative consumption of tramadol, respiratory rate, systolic and diastolic arterial pressure, heart rate, side effects and the time to first PCA demand were recorded 1, 2, 4 and 24 h after surgery. In group K, the time to respond commands was statistically lower than group T. Increases in respiratory rate, heart rate and sedation score at 4 and 24 h in group K were significantly more different than group T. Postoperative analgesic requirement between groups was not found statistically significant. We concluded that compared with thiopental, using ketamine which has analgesic properties during induction period provided better emergence, analgesia till postoperative 1h and sedation during first 24h and that thiopental and ketamine used during induction period didn’t affect postoperative analgesic requirement.

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