Özet:

LEPTIN, known as the adiposite source hormone, plays an important role in nutrition and energy homeostasis. Leptin regulates central or peripheral complex biological effects through its receptors. The mechanisms that link obesity and associated Leptin resistance greatly preserve its uncertainty. Also, the non-calcemic effects of vitamin D play a prospective role on the hormonal regulation of glucose metabolism and the synthesis of adipokins with fat tissue. The aim of our study is to show the role of vitamin D levels on obesity and the activity of leptin levels during vitamin D differentiation in obesity patients. Tools and Methods: 40 obese and healthy patients were included in this study to analyze the levels of vitamin D. In individuals with low vitamin D levels, 4 weeks of vitamin D treatment was administered. Blood was taken from all the test groups for the measurement of leptin. Results: In the group of patients with low levels of vitamin D, Leptin expression has been reduced; during vitamin D supplement, the levels of Leptin in obese patients have increased significantly. This means that leptin is an important determinant for the detection of obesity, which is directly related to the vitamin D level. Result: These results show that increased serum vitamin D levels provide healing in Leptin sensitivity. Future clinical trials should be tested. Vitamin D change can be a diagnostic factor for obesity associated with leptin discharge. Keywords: Body Mass Index; Leptin Expression; Obesity; Vitamin D ABSTRACT Objective: Adipocyte-induced hormone Leptin, nutrition and energy play an important role in homeostasis. Leptin regulates central or peripheral complex biological effects through its receptors. The mechanisms linking obesity and associated Leptin resistance remain largely unclear. Also noncalcaemic effects of vitamin D, perspective role is played on hormonal regulation of glucose metabolism and synthesis of adipokines by fat tissue. The aim of our study is to show the role of vitamin D levels on obesity and the activity of Leptin levels during vitamin D differentiation on obese patients. Material and Methods: Fourty obese and healthy patients were included this research to analyze vitamin D levels. While seen low-vitamin D level in individuals, 4 weeks vitamin D treatment has been completed. Whole experimental groups were taken blood for Leptin measurement. Results: Our findings were indicated that Leptin expression was decreased when vitamin D levels in low. However, during vitamin D uptake, Leptin levels in obese patients were increased correlated to deficiency. That means, Leptin is known significant marker to detect obesity which has direct relationship with vitamin D level. Conclusion: These results highlight that reduction serum vitamin D levels leads to improved Leptin sensitivity. Future clinical trials should be tested vitamin D alteration might be diagnostic factor for obesity treatment to Leptin secretion. Keywords: Body Mass Index; Leptin Expression; Obesity; Vitamin D Level

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