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Amaç: Kardiyopulmoner bypass sonrası oluşan akut böbrek hasarı (CPB-ABH) mortalite ve morbidite artışı ile ilişkilidir. Postoperatif dönemde ABH erken tanısını sağlayacak biyobelirteçler tedavi başarısını artırabilir. Bu çalışmanın amacı neutrophil gelatinase-associated lipocalin (NGAL) ve sistatin C (Cys C) seviyelerini ölçmek ve erken biyobelirteç olarak doğruluk ve güvenilirliği test etmektir. Gereç ve Yöntemler: Çalışmamız CPB kullanılarak uygulanan kalp cerrahisi sonrası ABH gelişen hastalarda kreatinin, NGAL ve Cys C düzeylerini karşılaştıran prospektif gözlemsel bir çalışmadır. Kırk üç hasta çalışmaya dâhil edildi. CPB'nin başlatılmasından sonra, önceden belirlenmiş iki zaman noktasında (6 ve 24 saat) NGAL ve Cys C için kan örnekleri alındı. Bulgular: AKIN sınıflamasına göre, 8 hasta (% 44) ABH gelişti, 35 (% 56) hastada ABH gözlenmedi. Tüm parametreler için işletim karakteristiği eğrisi altında kalan alan (AUCROC) hesaplandı. AUCROC değeri 6.saat NGAL için 0,81 (%95 CI:0,63-1,0 p=006) ve 24. Cys C. için 0,867 (95% CI: 0,00-1,00 p: 0,004) idi. Bu nedenle, 6. saat NGAL ve 24. saat Cys C değerleri ABH teşhisi için tanısal değere sahiptir. Sonuç: Çalışmamıza göre, 6. saatte NGAL ve 24. saatte Cys C düzeyleri, CPB-ABH erken teşhisi için güçlü bir tanısal değere sahiptir.
Purpose: Acute kidney damage (CPB-ABH) that occurs after cardiopulmonary bypass is associated with increased mortality and morbidity. Biobelirects that provide early diagnosis of ABH in the postoperative period can increase the success of treatment. The aim of this study is to measure the levels of neutrophil gelatinase-associated lipocalin (NGAL) and sistatine C (Cys C) and to test the accuracy and reliability as early biobelinders. Tools and Methods: Our study is a prospective observational study that compares the levels of creatine, NGAL and Cys C in developing patients with post-heart surgery applied using CPB. Thirty-three patients were involved in the study. After the launch of the CPB, blood samples for NGAL and Cys C were taken at two predefined time points (6 and 24 hours). Results: According to the AKIN classification, 8 patients (44 percent) developed ABH, 35 (56 percent) patients had no ABH observed. The remaining area under the curve of the operating characteristics (AUCROC) for all parameters has been calculated. The AUCROC value is 0.81 (95% CI:0,63-1,0 p=006) and 24. For Cys C. it was 0.867 (95% CI: 0.00-1.00 p: 0.004) . Therefore, 6 hour NGAL and 24 hour Cys C values have a diagnostic value for ABH diagnosis. Result: According to our study, NGAL at 6 hours and Cys C levels at 24 hours have a strong diagnostic value for CPB-US early diagnosis.
Aim: The development of acute kidney injury (AKI) after cardiopulmonary bypass (CPB) is associated with increased rates of mortality and morbidity. The identification of reliable biomarkers that allow earlier diagnosis of AKI in the post-operative period may increase the success of therapeutic interventions. The aim of our present study was to measure neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (Cys C) levels and to test the accuracy and reliability as an early biomarker. Material and Methods: The study was designed as a prospective observational study, comparing creatinine, NGAL, and Cys C levels in patients who develop AKI or not after heart surgery using CPB. Forty-three patients met the inclusion criteria. We obtained blood samples for NGAL and Cys C at two predetermined time-points (6 and 24 hours) after the initiation of CPB. Results: According to the AKIN classification, 8 patients (44%) developed AKI (AKI1 groups) and 35 (56%) did not (non-AKI). The areas under the receiver operating characteristic curve (AUCROC) values were calculated for all parameters. AUCROC value was 0.81 (95% CI: 0, 63 to 1, 00) for 6th hours NGAL and 0.867 (95% CI: 0, 00-1, 00, p: 0.004) for 24th Cys C. Therefore, NGAL measured in 6th hours and 24th Cys C, have diagnostic value for early diagnosis of acute kidney injury. Conclusion: Based on our study, NGAL levels measured in 6th hour, and Cys C levels measured in the 24th hour have high predictive value for early diagnosis for CPB-ABH.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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