Özet:

Object This study aims to determine seroprevalence of celiac disease (CD) in patients with presumed diarrhea predominant irritable bowel disease (IBS-D). Methods A total of 100 patients with presumed IBS-D (mean(SD) age: 42.8(16.8) years, 64.0% were females) were included in this crosssectional single-centre study. Data on patient demographics, smoking status, co-morbid psychiatric disorders and blood biochemistry were recorded. Seroprevalence of CD specific anti-tissue transglutaminase (anti-tTG) antibodies (anti-tTG IgA and anti-tTG IgG) and endomysial (EMA) antibody were determined, while demographic characteristics and laboratory findings were compared between CD seronegative and seropositive patients. Results Anti-tTG IgG antibody was positive in 17.0% of patients, as followed by anti-tTG IgA antibody positivity in 7.0% and anti-EMA antibody positivity in 12.0% of patients. Positive findings for at least one antibody was noted in 17(17.0%) patients including positivity for single antibody in 3(3.0%) patients, two antibodies in 9(9.0%) patients and three antibodies in 5 (5.0%) patients. No difference was noted between seropositive and seronegative patients in terms of gender, active smoking, co-morbid psychiatric disorder and laboratory findings. Conclusion In conclusion, our findings revealed that non-negligible percentage of patients with suspected IBS-D had positive serological findings for CD and thereby emphasize that “test and treat” strategy for CD in patients with presumed IBS-D may be worthwhile.

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