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bilgi işleme ve çalışma belleği yetersizliği ile karakterizedir. Bu çalışmada; KİS’li bireylerdeki bilişsel etkilenmenin özelliklerini ve sıklığını sağlıklı kontrollerle karşılaştırarak araştırmak amaçlanmıştır. Gereç ve Yöntem: Hastalara PASAT, COWAT, Stroop testi, RAVLT, Benton Çizgi Yönünü Belirleme testi, iz sürme testi, sayı dizileri testi uygulandı. Ayıca depresyon, yorgunluk ve yaşam kaliteleri de ölçeklerle değerlendirildi. Bulgular: Çalışmaya yaş ortalaması 36.3 olan 25 KİS hastası, yaş ve cinsiyet olarak eşleştirilmiş 22 sağlıklı kontrol alındı. Sağlıklı kontroller ile karşılaştırıldığında hastaların %52’si Stroop testinde başarısız oldular. COWAT’ta bu oran %60 olarak saptandı. RAVLT, BJLO, iz sürme testi ve sayı dizileri testi için bilişsel bozulma sıklığı göreceli olarak daha düşüktü. PASAT’da ise bu oran %20 olarak saptandı. Hastaların %21’inde en az iki testte bilişsel bozukluk saptandı. En az bir testte bozulma saptanan hasta oranı -1 SD ile %64, -2 SD ile %48 olarak saptandı. Yorgunluk ile KİS hastalarındaki bilişsel etkilenme arasında anlamlı bir ilişki saptandı. Sonuç: Çalışma grubunun % 21’inde, iki ya da daha fazla alt testte bilişsel bozulma görülmüştür. En belirgin olarak dikkat ve yürütücü işlevlerin etkilendiği saptanmış olup, bilişsel yorgunluk; Stroop, PASAT ve COWAT ile bağıntılıydı. KİS aşamasında, sosyal hayat ve hastalık seyri üzerine etkisi bilenen bilişsel etkilenme varlığı, sıklığı ve ayrıntılı tanımlanması belki de tedaviyi düzenleme aşamasında göz önünde bulundurulmalıdır.
Purpose: The cognitive profile in clinically isolated syndrome (CIS) is frequently characterized by deficit in processing speed and working memory. In this study, we aimed to investigate the characteristics and frequency of cognitive disorder in patients with CIS by comparing with healthy controls. Materials and Methods: All participants were tested with PASAT, COWAT, Stroop test, RAVLT, JLO, Trail Making Test, Digit Span. Depression, fatigue and quality of life were assessed by the scales. Results: In this study, 25 patients with CIS and 22 healthy controls matched by age and sex were included. Fifty-two percent of patients were failed at Stroop test in comparison to healthy controls, and this rate was indicated as 60% in COWAT. The frequency of cognitive impairment for the RAVLT, JLO, Trail Making Test, and Digit Span was relatively lower. Moreover, this rate was 20% in PAZAT. The cognitive impairment was found in two subtests of BICAMS at least, in 21% of patients. Those with at least one abnormal tests were shown 64% (-1SD), 48% (-2SD). There was a significant relationship between fatigue and cognitive impairment in patients with CIS. Conclusion: Cognitive impairment was found in two or more sub-tests of BICAMS; in 21% of our group. Attention and executive functions were distinctly found to be impaired in CIS, and cognitive fatigue was related to Stroop, PASAT and COWAT. The existence, frequency and detailed description of the cognitive disorder that has an impact on social life and disease course in the course of CIS should be taken into consideration.
Purpose: The cognitive profile in clinically isolated syndrome (CIS) is frequently characterized by deficit in processing speed and working memory. In this study, we aimed to investigate the characteristics and frequency of cognitive impairment in patients with CIS by comparing with healthy controls. Materials and Methods: All participants were tested with PASAT, COWAT, Stroop test, RAVLT, JLO, Trail Making Test, Digit Span. Depression, fatigue and life quality were assessed by the scales. Results: In this study, 25 patients with CIS and 22 healthy controls matched by age and sex were included. Fifty-two percent of patients were failed at Stroop test in comparison to healthy controls, and this rate was indicated as 60% in COWAT. The frequency of cognitive impairment for the RAVLT, JLO, Trail Making Test, and Digit Span was relatively lower. Moreover, this rate was 20% in PASAT. The cognitive impairment was found in two subtests of BICAMS at least, in 21% of patients. Those with at least one abnormal tests were shown 64% (-1SD), 48% (-2SD). There was a significant relationship between the fatigue and cognitive impairment in patients with CIS. Conclusion: Cognitive impairment was found in two or more sub-tests of BICAMS; in 21% of our group. Attention and executive functions were distinctly found to be impaired in CIS, and cognitive fatigue was related to Stroop, PASAT and COWAT. The existence, frequency and detailed description of the cognitive impairment that has an impact on social life and disease course in the course of CIS should be taken into consideration.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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