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Amaç: Besin alerjisi sıklığı dünya genelinde artış göstermektedir. Yumurta alerjisi süt alerjisinden sonra çocuklarda 2. sıklıkta görülmektedir. Kızamık, kızamıkçık, kabakulak (KKK) aşısı, kızamık ve kabakulak virüsünün tavuk embriyo kültürlerinde üretilmesi nedeniyle eser miktarda yumurta proteini içermektedir. Bu nedenle yumurta alerjisi olan çocuklarda aşılamada çekinceler oluşmaktadır. Çalışmamızda yumurta alerjisi nedeniyle değerlendirilen süt çocuklarının 1 yaş KKK aşılaması sonrasında yan etkilerinin değerlendirilmesi amaçlanmıştır. Yöntem: Hastanemiz Çocuk Alerji İmmünoloji polikliniğinde Şubat 2018- Nisan 2019 tarihleri arasında yumurta alerjisi nedeniyle takip edilen ve kliniğimizde 12. ayda KKK aşısı uygulanmış olan 44 olgu çalışmaya alındı. Olguların demografik verileri, klinik bulguları, cilt prick testleri, bakılmış olan vakaların total IgE, eozinofil, alerjen spesifik IgE düzeyleri, aşılama sonrası yan etki profilleri retrospektif olarak değerlendirildi. Bulgular: Olguların 24’ü (%54,5) kız, 20’si (%45,5) erkekti. Hastaların 31’inde (% 70,4) atopik dermatit, 7’sinde (%15,9) ürtiker/döküntü, 6’sında (%13,6) reaktif havayolu hastalığı tanıları mevcuttu. Olguların cilt prick testlerinde 31 olguda (% 70,5) yumurta beyazı, 26 olguda (%59,1) yumurta sarısı ile pozitif reaksiyon saptanmıştı. KKK aşılaması yapılan 44 süt çocuğundan 4’ünde (%9) reaksiyon gözlenmiş olup 3 olguda ilk 4 saatte, 1 olguda ilk 24 saatte reaksiyon gelişmiştir. Olguların hiçbirinde hayatı tehdit eden ciddi reaksiyon gözlenmemiştir. Sonuç: Bağışıklamanın önemi dikkate alındığında anaflaksi riskinin düşük olması nedeniyle yumurta alerjisi olan çocuklarda aşı güvenle yapılabilir. Ancak atopik çocuklarda aşının, acil müdahale edilebilecek uygun koşullarda yapılması ve uygun süre gözlem altında kalmalarının önemli olduğunu düşünüyoruz.
Purpose: The frequency of food allergies is increasing worldwide. Egg allergy is most common in children after milk allergy. A vaccine for grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit, grapefruit and grapefruit. This is why children with an allergy to eggs are concerned about vaccination. Our study is aimed at assessing the side effects of milk children assessed due to egg allergy after 1 year of KKK vaccination. Method: In our Hospital Children's Allergy Immunology Clinic from February 2018 to April 2019 the 44 cases followed due to egg allergy and in our clinic the 12th month KKK vaccine was applied were taken to study. The demographic data of the cases, clinical findings, skin prick tests, total IgE, eosinofil, allergen-specific IgE levels of cases, post-vaccination side effects profiles were evaluated retrospective. Results: 24 of the cases (54,5%) were girls and 20 (45,5%) men. 31 patients (70.4 percent) had atopic dermatitis, 7 (15.9 percent) had urethritis and 6 (13.6 percent) had reactive aircraft disease diagnoses. In the skin prick tests of the cases, 31 cases (70,5%) had an egg white and 26 cases (59.1) had an egg yellow positive reaction. 4 of the 44 milk-vaccinated children (9%) observed a reaction in 3 cases in the first 4 hours and 1 in the first 24 hours. No serious life threatening reaction has been observed. Result: Considering the importance of immunity, the vaccine can be made safely in children with an egg allergy due to the low risk of anaphylactic disease. But we believe that vaccination in atopic children is important to be performed in appropriate conditions that can be urgently interfered and to be observed for the appropriate time.
Aim: Food allergy prevelance is increasing in the childhood. Egg allergy isth e second most common allergen after the milk. Measles, mumps, rubella (MMR) vaccines can contain trace amount of egg protein due to the live virus produced in the chick embryo cultures. So it could be some concerns about vaccination of egg allergic infants. In our study, we aim to evaluate the side effects of egg allergic infants after MMR vaccination that applied to 12 months olds. Material and Methods: Fourty four egg allergic patients who were following up and vaccinated on the 12 months between February 2018 and April 2019 enrolled in the study. Demographic features, clinical diagnoses, skin prick tests, spesific IgE tests, eosinophils, total IgE levels from evaluated patients and side effects after vaccination were evaulated retrospectively. Results: Twenty four (54,5%) patients were female, 20 (45,5%) patients were male. Thirthy one (70,4%) patients had atopic dermatitis, 7 (15,9%) patients had urticaria/rash, 6 (13,6%) patients had reactive airways disease. In the skin prick tests 31 (70,5%) patients had sensitivity to egg whites, 26 (59,1%) patients had sensivity to egg yolk. Four (9%) of 44 patients from vaccinated with MMR had side effects. Reactions had been observed in the first 4 hours in 3 patients and in 24 hours in one patient. There was no severe side effect in any patients. Conclusion: Considering the importance of immunization, MMR vaccine could ap-ply safely in egg allergic patients due to very low anaphylaxis risk. But we think that the vaccine should be made with emergency aid conditions in atopic children and they should be kept in proper time.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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