Abstract:

Objective: COVID-19 disease, can lead to respiratory failure by causing acute lung injury. Due to the high mortality risk; it is important to predict the protection of antibody levels after infection. In our study, it was aimed to examine the demographic characteristics of patients who were found to have COVID-19 disease, were not vaccinated and whose blood antibody response was checked during follow-up and to evaluate the relationship between antibody levels and lung involvement of disease. Materials and Methods: 118 patients who were proven to have COVID-19 disease and were not vaccinated were included in the study. Their demographic information was recorded. Antibody levels were determined. Chest X-ray or tomography images were examined to evaluate lung involvement. Results were compared with antibody levels. Results: Of the 118 patients, 56 were male and 62 were female. The antibody level was positive in 76 people (64.4%). The mean antibody titer was 63.76±54,88. Lung involvement was found in 14 (11.9%) of the patients. Antibody levels of patients with lung involvement were higher than those without lung involvement (p<0.001). It was observed that lung involvement developed more in male compared to females (p= 0.048). Conclusion: In unvaccinated individuals, lung involvement was found to be higher in men. Antibody levels of patients with lung involvement were higher than those without. Although the children did not have lung involvement, the immune response was high. It should be kept in mind that antibody levels may be lower after mild illness. Adult individuals should be vaccinated with priority.

Keywords: