Özet:

Periodontitis is a chronic inflammatory disease that is characterized by destruction in the tooth support tissues and has different forms. Growth arrest-specific protein 6(Gas6) is a protein that regulates cell proliferation, adhesion, migration, fagositosis and adiposite development of apoptotic cells by macrophages; a protein that plays a role in the pathogenesis of chronic diseases such as obesity, diabetes mellitus and aterosclerosis. In our knowledge, the literature has not studied the relationship of Gas6 protein with periodontal disease. The aim of this study is to explore the role of Gas6 protein in periodontal tissue destruction and to illuminate the place of this molecule in the periodontal disease pathogenesis. The study included 20 individuals with systematically healthy (8 women, 13 men) and systematically and periodontally healthy (7 women, 12 men) who were appliced for treatment in the Periodontology Clinic and diagnosed with periodontitis (Ere III, degree B, generalized). Examples of scratch were taken prior to clinical periodontal index measurements (Sondalamada cell depth (SCD), sondalamada bleeding index (SKI), dental withdrawal (DC), plaque index (PI) and clinical attack loss (KAK). Gas6 anti-inflammatory protein was studied in samples of sputum collected using the ELISA method. The results were evaluated using the IBM SPSS Statistics 22 program by Mann Whitney U test, Continuity (Yates) Correction and Ki-Kare test. Results: All clinical periodontal index values of patients with periodontitis were statistically significantly higher than healthy individuals (p:0.001;p<0.01). Gas6 protein levels in scratch have not shown a statistically significant difference between periodontitis and healthy individuals. Results: According to the results of this study, gas6 protein was detected in the sputum of individuals with periodontitis. However, it should be discussed whether Gas6 has a possible role in the pathogenesis of periodontitis. Advanced studies are needed, including serum and dental fluid samples, and the relationship between anti-inflammatory proteins and pro-inflammatory cytokines can be evaluated. Keywords: Gas6, Periodontitis, Evaluation of the effect of periodontal status on saliva Growth arrest-specific protein 6(Gas6) Aim: Periodontitis is a chronic inflammatory disease which is characterized by the destruction of tooth supporting tissues and has various forms. Growth arrest-specific protein 6(Gas6), is a protein that regulates cell proliferation, adhesion, migration, phagocytosis of apoptotic cells by macrophages and adipocyte development and also has roles on the pathogenesis of chronic diseases such as obesity, diabetes mellitus and atherosclerosis. To the best of our knowledge, the relationship between Gas6 protein and periodontal disease has not been investigated in the literature. The aim of this study was to investigate the role of Gas6 protein in periodontal tissue destruction and to elucidate the role of this molecule in the pathogenesis of periodontal disease. Material and Method: Twenty systematically healthy (8 female, 13 male) patients with periodontitis (stage III, grade B, generalized) admitted to the periodontology clinic for treatment and systematically and periodontally healthy 20 individuals (7 female, 12 male) were included in the study. Saliva samples were taken before the measurement of clinical periodontal indices (Probing pocket depth(PPD), bleeding on probing (BOP), gingival recession (GR), plaque index (PI) and clinical attachment loss (CAL). Gas6 anti-inflammatory protein in saliva samples was examined by ELISA method. Results were evaluated by Mann Whitney U test, Continuity (Yates) correction and Chi-Square test using IBM SPSS Statistics 22 program. Results: All clinical periodontal index values of patients with periodontitis were significantly higher than healthy subjects (p: 0.001; p <0.01). Gas6 protein level in saliva did not show a statistically significant difference between periodontitis and healthy individuals. Conclusion: According to the results of this study, Gas6 protein was detected in the saliva of periodontitis patients. However, it is controversial whether Gas6 has a possible role in the pathogenesis of periodontitis. Further studies are needed to include serum and gingival fluid samples and to evaluate the relationship between anti-inflammatory proteins and pro-inflammatory cytokines. Key Words: Gas6, Periodontitis, Saliva

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