Abstract:

The aim in our clinic is to make a retrospective analysis of the facts applied to amniyosenthesis and to contribute to literature by sharing our experience on this subject. The study included 632 cases of amniyosentez applied in the second trimester. The demographic characteristics of the incidents, the weeks of pregnancy, the indications of amniyosentez, the processing-related complications, the success of culture, the cytogenetic results, the results and indications of the incidents identified with chromosome anomaly were assessed. Chromosome anomaly, complications, cultural failure rates and most frequent amniyosentez indications were indicated. The results of the phenomena with chromosome anomalies were indicated as numerical and structural anomalies. The average age of all the incidents included in our study is 33.7±6.8 years, the pregnancy weeks are 17.5±1. It was found for 0 weeks. Chromosome anomaly caused by amniyosentez was detected by 22.4%, culture failure by 2.1%, and complication by 0.5%. The most common indications of amniyosentez and chromosome anomaly are the same in cases where amniyosentez indications are the same, respectively; the combined test is high risk, the triple screening test is high risk, and the ultrasound (USG) anomaly. The rate of detection of chromosome anomaly was higher in cases where more than one indication was observed together and amniyosentez was applied. The result is that USG and serum screening tests are widely used for prenatal diagnosis while high-risk patients need invasive tests such as amniyosentez for accurate diagnosis. In cases with the risk of multiple chromosome anomalies in screening tests, amniyosenthesine was more important for prenatal diagnosis.

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