Özet:

The purpose of the study is to investigate the role of vitamin D in the hypersensitivity ethology in infants with high calcium levels and to determine the factors affecting the level of vitamin D. Tools and Methods: Our study was carried out between January and December 2012 at 53 infants with basically high calcium (≥10mg/dl) in the Children's Health and Diseases Clinic of Konya Education and Research Hospital. The Infants were divided into two groups: Group I (1-6 months) and Group II (7-12 months). All babies in the study were applied and a month after vitamin D was interrupted, serum calcium, phosphorus, alkaline phosphatase (ALP), parathormone (PTH), 25(OH)D3 and spot urine calcium, creatine(ca/cr) levels were studied. Results: 44 of the patients (83 percent) were men, 9 percent (17 percent) were girls and the average age was 5.11±2.48 months. In babies who only receive breast milk, the serum level of 25(OH)D3 (41.48 ng/ml) was higher than in food areas. There was no significant difference between the levels of calcium, phosphorus, ALP, PTH and 25(OH)D3 between the 45 infant and the 8 infant using different doses (800-1200 IU/day) using the 400 IU/day preperate of vitamin D(p≥0,05). Patients were checked down to 25(OH)D3 levels after the vitamin D was interrupted, while calcium levels were seen at the same level. However, in the period of vitamin D deficiency, increased PTH and phosphorus were observed. The ALP values have not changed. Hypercalcium was not detected at the patient’s immediate application and controls. The result is a non-common electrolyte disorder that is often noticed accidentally in routine biochemical examinations. Although one of the reasons was the use of vitamin D, our study found that the intake of vitamin 1200 IU/day and below has no connection with hypercalcemia and hypercalcium. The Relationship of Hypercalcemia and Vitamin D in Infants ABSTRACT Objective: To investigate the role of vitamin D in the etiology of hypercalcemia in infants with calcium elevation and to determine the factors affecting vitamin D levels. Material and Methods: Our study was carried out in 53 infants with high calcium levels (≥10 mg / dl) who were hospitalized in the pediatric clinic of Konya Training and Research Hospital between a one year period. The patients were divided into two groups as Group I (1-6 months-old) and Group II (7-12 months-old). Serum levels of calcium, phosphorus, alkaline phosphatase (ALP), parathormone (PTH), 25 (OH) D3 and spot urine calcium and creatinine (ca / cr) levels were studied in all infants on admission and one month after vitamin D supplementation was stopped. Results: 44 (83%) of the patients were male and 9 (17%) were female and the average age was 5.11 ± 2.48 months. Serum 25 (OH) D3 levels (41.48 ng / ml) were significantly higher in infants who received only breast milk. There were no significant differences between 45 infants who received 400 IU / day vitamin D and 8 infants using different doses (800-1200 IU / day) in terms of calcium, phosphorus, ALP, PTH and 25 (OH) D3 levels (p≥0.05). 25 (OH) D3 levels were decreased and calcium levels remained the same after vitamin D supplementation was stopped. However, there was an increase in PTH and phosphorus levels in the period when vitamin D levels were low. ALP levels did not change. Hypercalciuria was not detected at the time of admission and the follow-up period of the patients. Conclusion: Calcium is a non-widespread electrolyte disorder, which is coincidentally detected during routine biochemical analysis. Although one of the reasons was the use of vitamin D, it was shown in our study that vitamin D intake of 1200 IU / day and below did not correlate with hypercalcaemia and hypercalciuria. Keywords: vitamin D, infant, calcium 0000-0003-0733-3943