Özet:

In order to investigate the role of bromocriptine (BCR) on immune response we have undertaken an experimental study and its results were compared with those of another immunosuppressive agent, Cyclosporine A (CsA). 63 mole Swiss albino rats were divided into 4 groups. Twenty two of those were used as a control and received intraperitoneal saline for 4 days. The other groups were treated with 3 mg/Kg CsA, 200 g/Kg of BCR and the combination of these two drugs for the same period. CsA treatment caused significant decrease in T cell proliferation and macrophage phagocytic activity, BCR showed similar depression both in the response of T cell and phagocytic activity. However the combination of these two drugs showed no additive effect on immune system. As a conclusion, a PRL secretion inhibitor BCR has been found to be a potent immunosuppressive agent which is comparable to CsA.

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