Abstract:

The aim of this study was to investigate the effects of isoflurane and sevoflurane anesthesia on the cardiovascular system during the experimental laparotomy. A total of 24 mongreal dogs were used in the study. The average weight of 12 dogs was 22.8±4 kg in isoflurane group and of 12 dogs was 26.3±5 kg in sevoflurane group. Atropine sulphate (0.04 mg/kg) was administered subcutaneously to dogs 30 min. before anesthesia. After 15 minutes of atropine administration to dogs, xylazine hydrochloride (2 mg/kg) was administered intramuscularly for sedation. The induction of anesthesia in both groups was provided by ketamine hydrochloride at 15 mg/kg intravenous dose. And then inhalation anesthesia with isoflurane or sevoflurane at 1.5 MAC was applied. Tidal volume was adjusted to 15 ml/kg and ventilation was 12 times per minute. Both arteria and vena femoralis were placed with a catheter by disection of sulcus femoralis. An experimental median line laparotomy was performed on all cases. After providing a hemodynamic stabilization in both groups parameters of heart rate (HR), average arterial pressure (MAP), central venous pressure (CVP), right ventricular pressure (RVP), pulmonary arterial pressure (PAP), pulmonary capillary wedge pressure (PCWP), and cardiac output (CO) were measured on the 0, 30, 60 and 120 minutes. Heart rates were determined as significantly (p<0.001) different at 0, 30, 60, and 120 min between two groups. MAP at 30 min, CVP at 0 and 60 min, and CO at 60 min between two groups were also statistically (p<0. 05) is different. Althougth HR, MAP, CVP, CO, RVP and PAP within in isoflurane group and MAP and RVP within sevoflurane group at 0, 30, 60, and 120 minutes were statistically significant (p<0.05),the values were within reference range. It was concluded that the effects of inhalation anaesthesia with isoflurane or sevoflurane on the cardiovascular system were similar in dogs which underwent to laparotomy surgery; therefore, both anesthetic drugs can be used in veterinary surgery.

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