Abstract:

I am. Gallbladder cancer (GBC) is often diagnosed at advanced stage and the prognosis is very poor. Information about the treatment of gallbladder cancer in the literature is limited. Most of the information was obtained from studies that involving liver, pancreas and other even duct cancer. There is no standard therapy for metastatic disease. Various chemotherapeutic agents are used in the metastatic disease. In our study, the effect of chemotherapy on survival in metastatic gallbladder cancer were investigated. The Methods. Medical records of 32 patients with metastatic gallbladder cancer were evaluated retrospectively. The result. Both overall survival and progression free survival was longer in 14 (43.8%) patients receiving chemotherapy. This diversity was statistically significant (p<0.001). Progression-free survival was 20 ± 2.9 (14.3-25.7% CI) weeks and overall survival was 36 ± 11.2 (14-58% Cl) weeks in the patients receiving chemotherapy. On the other hand progression-free survival was 4 ± 0.4 (3.2-4.8% CI) weeks and overall survival was 12 ± 2.8 (6.5 x 17.5% CI) weeks in patients that didn’t receive chemotherapy. Gemcitabine/cisplatin and cisplatin/5-fluorouracil combinations were the most commonly used regimen. and Conclusion. This study suggests that the positive effect of chemotherapy on survival in metastatic gallbladder cancer

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