Özet:

The article presents two clinical cases of rare zoogenous professional viral infectious disease caused by DNA-containing parapoxvirus, which is transmitted directly during contact, most often in the milking of cows, which also caused the disease to be called "milker’s nodules", but the risk of infection is also subject to butchers, farmers and agro-tourists. The clinical course of two cases of paravaccinia is described in detail, the virus infection begins 5-15 days after inoculation in the form of a violet erythematous rounded node with a clear compression in the center and surrounding its erythematous ring. The need for a clear elucidation of the epidanamnesis, which may facilitate differentiation with the Rhizenbach erysipeloid, skin neoplasms, contagious mollusks and anthrax carbuncle, is emphasized. According to modern literature, in farms, the appearance of nodules may occur in people with impaired immunity, which also has an increased risk of serious complications. The nodules independently dissolve in persons without weakened immunity and heal without the formation of a scar. There is evidence that a para-vaccine virus can become a source of antigen for the development of multiform erythema. Analyzing the data of professional foreign and domestic articles, paravaccinia is a self-limiting viral infection, the prevention of which is reduced to compliance with sanitary and hygiene rules for milking cows, animal care, the use of antiseptics in veterinary and farm. Scientific interest in the study of the state of the immune system is susceptible to the virus, especially the clinical course of the comorbid immunodeficiency pathology of various genesis, since the question remains unclear. The unique structure and replication process of parapoxviruses is being intensively investigated, and these data may open up promising therapeutic options for treating cancer. General practitioners-family medicine and practitioners of other specialties-infectious disease specialists, dermatologists, oncologists and surgeons should remember the features of this infection, since the high probability of misidentification for persons who had not previously met her could lead to unwanted use of too intense methods of treatment Author Biographies Andrii Sokol, Higher state educational establishment “Bukovinian State Medical University” Teatralna sq., 2, Chernivtsi, Ukraine, 58002 PhD, Professor Department of Internal Medicine and Infectious Diseases

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