Özet:

Purpose: PBC is frequently associated with other autoimmune diseases, especially with autoimmune thyroid disease. Studies showed 14-24% prevalence of autoimmune thyroid disease and anti-thyroid antibodies vary considerably in primary biliary cholangitis (PBC). The aim of the present study was to investigate thyroid autoimmunity in patients with PBC.                                             Methods: This study was based on data derived from the medical files of 263 consecutive PBC patients treated in the gastroenterology department of our tertiary care center between June 1999 and August 2017. Thyroid autoimmunity was defined as Anti TPO and/or Anti TG above the normal range. The differences in clinical features and laboratory findings of PBC patients with and without autoimmune thyroid disease were documented.                                       Results: The average age was 55.0±12.4 (28-84) and 244 (92.7%) patients were female. Thyroid autoimmunity was evident in 80 patients (30,2%) of our series. There were 19 patients in non-autoimmune thyroid diseases group, 15 patients with multinoduler goiter, 3 patients with toxic thyroid nodul and one patient with thyroid cancer. We found 9 hyperthyroid patients in non-thyroid autoimmune group, 3 patients with toxic thyroid nodul, one patient with acute thyroiditis and 5 patients with other thyroid diseases. One patient who had toxic thyroid nodul was determined as thyroid papillary microcarcinoma. Thyroid autoimmunity is frequently seen in PBC patients. There were no significant clinical parameters differences in our study. However, patients with PBC should be screened for thyroid disease.

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