Abstract:

I am. Nitric oxide synthesis, 3-isoform in the nitric oxide synthase is regulated by the enzyme. These endothelial nitric oxide synthase (eNOS), neuronal nitric oxide synthase (nNOS) and inducible nitric oxide synthase (iNOS). eNOS regulates the diameter of arterial vessels. Functional activity is outside the structural activity. In this study, eNOS gen, a structural vascular pathology of the two polymorphisms which compared the relationship between ruptured intracranial aneurysm. The Method. Endothelial nitric oxide synthase gene intron 4 (27 base pair repeat) and promoter T786C polymorphism of 43 patients with ruptured intracranial aneurysms and 46 control subjects were analyzed by polymerase chain reaction and DNA sequencing method. Genotype distribution and allele frequencies of endothelial nitric oxide synthase gen polymorphism in patients with ruptured intracranial aneurysm and healthy subjects were compared. The result. The CC genotype frequency was significantly higher in patients with ruptured intracranial aneurysm. It was also found that the presence of eNOS 786 CC genotype was significantly associated with the risk of intracranial aneurysm rupture (p<0.05). No significant difference was found between patient and control groups as to endothelial nitric oxide synthase gene intron 4 (27 base pair repeat) polymorphism (p>0.05). and Conclusion. T786C polymorphism in endothelial nitric oxide synthase gene seems to be a possible risk factor for intracranial aneurysm rupture

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