In this work, a comparative exergy analysis of cascade cooling system working with alternative refrigerant couples has been carried out. In study; R454C and R-744 as low temperature cycle (LTC) refrigerant and R1234ze, R1234yf and R717 as high temperature cycle (HTC) refrigerant were used. The refrigerants used in the study have zero ODP and low GWP values. Exergy analysis was carried out to investigate the effect to exergy efficiency of operation parameters in cascade cooling system. The exergy efficiency values of the cascade cooling system decreases with increasing evaporator temperature for all refrigerant couples. The exergy efficiency values of the cascade cooling system decreases with increasing the condenser temperature. Obtained results show that in all cases, the refrigerant couple R454C/R717 has the highest exergy efficiency.
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