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SARS-CoV-2 enfeksiyonununa karşı pandeminin erken döneminde, hastalığı tedavi edebilecek etkinliği bilimsel olarak kanıtlanmış bir tedavi bulunmamakla birlikte, tanı alan hastaların sağlık durumlarının ciddiyetine göre her ülkede farklı tedaviler uygulamaktadırlar. Bu çalışmada, COVID-19 pandemisinin erken döneminde teda-vide kullanılabilecek potansiyel tedavi seçenekleri üzerine yapılan bilimsel çalışmalar ile ilgili hızlı bir gözden geçirme yapılması amaçlanmıştır. Literatür taraması, OVID-MEDLINE, Web of Science ve Dergipark veri tabanlarında 01.01.2020-25.04.2020 tarih aralığını kapsayacak şekilde yapılmıştır. Tarama sonucunda top-lam 629 çalışmaya ulaşılmış ve değerlendirme sonrasında kalan 25 çalışma tam metin değerlendirmesine tabi tutulmuştur. Sonuç olarak; COVID-19 pandemisinin erken döneminde, hastalığın tedavisine yönelik etkinliği henüz bilimsel olarak kanıtlanmış bir tedavinin bulunmadığı, ancak farklı ilaçların potansiyel etkileri ile ilgili güçlü kanıtlar elde edebilmek için klinik çalışmaların halen devam ettiği ve mevcut ilaç seçeneklerine de potan-siyel yan etkiler açısından dikkatli yaklaşılması gerektiğinin vurgulandığı görülmüştür. Tedavide kullanılabile-cek ilaçların etkilerine ilişkin tartışmaların geniş çaplı klinik araştırmalardan gelecek kanıtlarla cevaplanabile-ceği düşünülmektedir.
In the early period of pandemic against SARS-CoV-2 infection, although there is no scientifically proven treatment for the effectiveness of the disease, different treatments are applied in each country depending on the severity of the health conditions of the diagnosed patients. This study aims to conduct a quick review of scientific studies on potential treatment options that can be used in the early period of COVID-19 pandemic. The literature scan, OVID-MEDLINE, Web of Science and magazine databases have been carried out to cover the date range of 01.01.2020-25.04.2020. The scan resulted in top-lam 629 studies, and the remaining 25 studies after the evaluation were subjected to full text evaluation. As a result, in the early period of COVID-19 pandemic, there was no scientifically proven treatment for the disease’s effectiveness yet, but clinical studies were still ongoing in order to obtain strong evidence of the potential effects of different medicines and it was emphasized that the existing medication options should also be carefully approached in terms of potan-near side effects. The discussions on the effects of medications in the treatment are considered to be answerable with future evidence from extensive clinical research.
Although there is no proven effective treatment against SARS-CoV-2 infection in the early period of the pan-demic, countries apply different treatments according to the severity of health status of patients. In this study, it is aimed to conduct a rapid review of scientific studies on potential drug options that can be used in early treatment of the COVID-19 pandemic. The literature review has been conducted in OVID-Medline, Web of Sci-ence and Dergipark databases in between the dates 01.01.2020-25.04.2020. As a result of the review, a total of 629 study have been accessed and after the assesment being made 25 studies were subject to full text evalua-tion. In the study, as a result we have seen at the early stage of COVID-19 pandemic that there have been no drugs that the efficacy has been yet proved scientifictly. However, we have also seen that there are ongoing clinical trials in order to obtain strong evidence pertaining potential effects of the different kind of medicines and it has also been emphasized that there is a requirement to be cautious in terms of the potential side effects of current drugs. We believe the evidence obtained from the large-scale clinical trials will respond the ongo-ing debates for the effects of these medicines.
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