Abstract:

Background:Hypothyroidism has been reported as one of the most common forms of thyroid disorder worldwide. Studies claim that this clinical state is caused by deficiency of thyroid hormone due production to functional and/or structural abnormalities. Diastolic dysfunction is the abnormality of functioning of the diastolic elasticity, distensibility or relaxation of the left ventricle. This is active regardless of the normality of left ventricle ejection fraction or the symptomatic or asymptomatic of the patient. Aims: The aim of the study will be to examine the effects of diastolic dysfunction among patients of hypothyroidism. Research questions:1. What percentage of hypothyroid patients have left ventricle diastolic hypothyroidism?2.Can diastolic dysfunction be reversed by thyroxine treatments?3.Does any correlation exist between Doppler echocardiography findings and serum TSH regarding left ventricle diastolic dysfunction?Materials: In this study, 100 hypothyroidism patients were included. The sample was divided into two groups: the first group consisted of patients with normal levels of TSH, FT3 and FT4, the second group consisted of patients with normal TSH but lower than 10 mU/L with normal FT3 and FT4. Tests like Eliza, spirometry and echocardiography for left ventricular diastolic dysfunction assessment. Results: This study found that in group 1 there was lower TSH, FT3, E/A ratio with an increase of A wave velocity, reduction of E wave velocity, prolongated DT, inter-ventricular relaxation time, and low percentage of FVC, FEV1, FEF25-75. The results also showed a negative connection between TSH and E wave velocity and E/A ratio but a positive connection between the three pulmonary function indices and IVRT. Conclusion: Hypothyroid patients, mostly of subclinical hypothyroidism are prone to left ventricular diastolic dysfunction. As a result, they should be screened by Doppler echocardiography for early diagnosis.

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