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D vitamini kasların gelişmesinden, kasılmasından ve yenilenmesinden sorumlu önemli bir moleküldür ve nükleer reseptör grubunun bir üyesi olan vitamin D reseptörü (VDR) reseptörleri aracılığıyla biyolojik fonksiyonlarını aktive eder. Bu çalışmada, Türk rugby oyuncularında rs731236 dağılımını analiz etmeyi amaçladık. Çalışmaya toplam 22 erkek oyuncu ve 30 sedanter birey (kontrol grubu olarak) katıldı. DNA izolasyonunu takiben, VDR'nin rs731236 polimorfizmleri gerçek zamanlı polimeraz zincir reaksiyonu (Rt-PCR) ile belirlendi. İstatistiksel analiz ki-kare testi ile yapıldı. Sporcularda rs731236 polimorfizmi için CC, CT ve TT genotip ve yüzde dağılımları sırasıyla 5 (%23), 10 (%45) ve 7 (%32) olarak bulundu. Alel dağılımları C aleli için 20 (%45) ve T aleli için 24 (%55) olarak bulundu. Kontrol grubu için CC, CT ve TT genotipleri ve yüzdeleri sırasıyla 4 (%13), 17 (%57) ve 9 (%30)’dur. C aleli kontrol grubu için 25 (%42) ve 35 (%58) olarak belirlendi. Sporcular ve kontrol grubunu genotip açısından karşılaştırdığımızda istatistiksel olarak anlamlı bir fark tespit edilmedi (p= 0,12). Alel karşılaştırması için gruplar arasında anlamlı fark tespit edilmemiştir (p= 0,76). Sporcularda gen kombinasyonlarının belirlenmesi optimal antrenman programlarının yürütülmesi için büyük önem taşımaktadır. Bu nedenle atletik performansla ilgili alellerin başarılı sporcular üzerindeki dağılımını belirlemeyi amaçladık. Bizim kohortumuzda CT genotipi ve T aleli oyuncularda daha yoğun olarak belirlendi.
Vitamin D is an important molecule responsible for the development, accumulation and regeneration of muscles and activates its biological functions through the vitamin D receptor (VDR) receptors, which are a member of the nuclear receptor group. In this study, we aimed to analyze the distribution of rs731236 in Turkish rugby players. The study included a total of 22 male players and 30 sedanter individuals (as a control group). Following DNA isolation, VDR's rs731236 polymorphisms were determined by real-time polymerase chain reaction (Rt-PCR). The statistical analysis was performed by Ki-Care test. Athletes found CC, CT and TT genotypes and percentage distribution for rs731236 polymorphism as 5 (%23), 10 (%45) and 7 (%32) respectively. The alel distribution was found as 20 (45) for the alel C and 24 (55) for the alel T. For the control group; CC, CT and TT genotypes and percentages are 4 (%13), 17 (%57) and 9 (%30) respectively. The C alel was determined as 25 (42) and 35 (58) for the control group. When comparing athletes and the control group in terms of genotype, there was no statistically significant difference (p=0.12). There is no significant difference between the groups for the comparison of alel (p=0.76). Identification of genetic combinations in athletes is of great importance for the implementation of optimal training programs. Therefore, we aimed at determining the distribution of the fields related to athletic performance over successful athletes. In our cohorte, CT genotype and T allies were more intensely determined in players.
Vitamin D is an important molecule responsible for the development, contraction and regeneration of muscles, and activates its biological functions by means of its receptors, the vitamin D receptor (VDR), which is a member of the nuclear receptor group. In the present study, we aimed to analyze the rs731236 distribution in Turkish rugby players. A total of 22 male players and 30 sedentary individuals (as a control group) participated in the study. Following DNA isolation, rs731236 polymorphisms of VDR was determined by real-time polymerase chain reaction (RT- PCR). Statistical analysis was carried out by chi-square test. CC, CT and TT genotype and percentage distributions for rs731236 polymorphism in players were as 5 (23%), 10 (45%) and 7 (32%), respectively. Allelic distributions were found to be 20 (45%) for C allele, and 24 (55%) for T allele. For the control group; CC, CT and TT genotypes and percentages were as 4 (13%), 17 (57%) and 9 (30%), respectively. C allele was counted as 25 (42%) and 35 (58%) for controls. When we compare athletes and control groups in the terms of genotypes, we detected no statistically significant difference (p= 0.12). For the allele comparison, we detected no significant difference between groups (p= 0.76). Determination of gene combinations in athletes is of great importance for carrying out of the optimal training programs. Therefore, we aimed to determine the distribution of the alleles related with athletic performance on successful athletes. In our cohort, the CT genotype and T allele were more intensely determined in players.
Dergi Türü : Uluslararası
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