Görüntüleme
27
İndirme
2
Amaç: Myelodisplastik sendrom hematopoetik sistemin klonal kök hücre hastalığıdır. Myelodisplastik sendrom, 65 yaş üzerinde erkeklerde daha sık görülen bir hastalıktır. Prognoz tayininde sitogenetik inceleme, kemik iliğindeki blast sayısı ve sitopeninin derecesinin eklenmesi ile Uluslarası Prognoz Puanlama Sistemi (IPSS) kullanılır. Yüksek riskli myelodisplastik sendrom hastalarında kronik hastalıkların sağ kalım üzerine etkisi ve prognostik değerini tespit etmek üzere bu çalışma planlandı. Yöntem: 2011 ocak ve 2019 ocak yılları arasında Mersin Üniversitesi Tıp Fakültesi Hematoloji polikliniğinde MDS tanılı hastalar retrospektif olarak değerlendirildi. 18-96 yaş arası, kronik hastalık varlığı tanı anında veya öncesinde mevcut olan, kemik iliği biyopsisi ile MDS tanısı konan 124 hasta çalışmaya alındı. Kategorik değişkenler sayı ve yüzde olarak belirtildi. Mortalite ile ilişkili bulgular univariable Cox regression analiz ile değerlendirildi. Bulgular: Hastaların ortalama yaşı 67 yıldı. Kardiyak hastalık, serebrovasküler hastalık, kanser ve kronik obstruktif akciğer hastalığı mortalite riskini arttıran olası risk faktörleri olarak saptandı. Yaşın 1 yıl artması 1,03 kat mortalite riskini arttırdığı saptandı. Kardiyak hastalığı olanlar olmayanlara kıyasla 1,60 kat mortalite riskine sahipti. KOAH olanlar olmayanlara kıyasla 1,78 kat mortalite riskini sahipti. Sonuç: İleri yaş, kardiyak hastalık, serebrovasküler hastalık, kanser ve kronik obstruktif akciğer hastalığı mortalite riskini arttıran olası risk faktörleri olarak saptandı. Bu çalışma MDS üzerine Mersin bölgesinden yapılmış tek merkezli en fazla hasta sayısına sahip olan ilk çalışma olması nedeni ile önemlidir. Bununla birlikte elde ettiğimiz bu verilerin Mersin’de yaşayan MDS hastalarında kronik hastalık varlığının mortaliteye etkisi ve en uygun tedavi seçeneklerini belirlemeye ışık tutacağını düşünmekteyiz.
Purpose: Myelodisplastic syndrome is a clonal root cell disease of the hematopoetic system. Myelodisplastic syndrome is a disease that is more common in men over the age of 65. The International Prognosis Score System (IPSS) uses cytogenetic examination, the number of blasts in the bone marrow and the addition of the degree of cytopenin. This study was planned to identify the impact and prognostic value of chronic diseases on survival in patients with high-risk myelodisplastic syndrome. Method: Patients diagnosed with MDS in the Hematology Clinic of the Mersin University School of Medicine between January 2011 and January 2019 were evaluated as retrospective. From 18 to 96 years old, 124 patients diagnosed with MDS were taken to study, which were present at or before the diagnosis of the presence of chronic disease, with bone marrow biopsy. Categorical variables are indicated as number and percentage. Results related to mortality were evaluated by univariable Cox regression analysis. The average age of patients is 67 years. Heart disease, cerebrovascular disease, cancer and chronic obstructive lung disease have been identified as potential risk factors that increase the risk of mortality. The age of 1 year increases the risk of mortality by 1,03 times. The risk of heart disease was 1.60 times higher than those who did not have heart disease. The risk of mortality was 1.78 times higher than those who did not. The result: Advanced age, heart disease, cerebrovascular disease, cancer and chronic obstructive lung disease were identified as potential risk factors that increase the risk of mortality. This study is important with the reason that it is the first study that has the number of patients with a single centralization made from the MDS area. However, we believe that the data we obtain will keep the light to determine the effects of the presence of chronic disease in MDS patients living in Mersin and the appropriate treatment options.
Aim: Myelodysplastic syndrome is a clonal stem cell disease of the hematopoietic system. Myelodysplastic syndrome is a more common disease in men over 65 years of age. Prognosis is determined by the addition of cytogenetic examination, bone marrow blast number and degree of cytopenia and the International Prognosis Scoring System (IPSS). This study was planned to determine the effect of chronic diseases on survival and prognostic value in patients with high risk myelodysplastic syndrome. Method: Between January 2011 and January 2019, patients diagnosed with MDS in the Hematology outpatient clinic of Mersin University Medical Faculty were evaluated retrospectively. A total of 124 patients aged 18-96 years, who were present before or at the time of diagnosis of chronic disease, were diagnosed as MDS by bone marrow biopsy. Categorical variables were expressed as numbers and percentages. Mortality-related findings were evaluated by univariable Cox regression analysis. Results: The mean age of the patients was 67 years. Cardiac disease, cerebrovascular disease, cancer and chronic obstructive pulmonary disease were identified as possible risk factors increasing the mortality risk. It was found that increasing age 1 year increased the risk of mortality 1.03 times. Those with cardiac disease had a 1.60-fold mortality risk compared to those without. Those with COPD had a 1.78-fold mortality risk compared to those without.. Conclusion: Advanced age, cardiac disease, cerebrovascular disease, cancer and chronic obstructive pulmonary disease were identified as possible risk factors that increased mortality. This study is important because it is the first study with the highest number of patients with single center in Mersin region on MDS. However, we think that these data will shed light on the effect of the presence of chronic disease on mortality and the most appropriate treatment options in MDS patients living in Mersin.
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
Makale Detay 
Benzer Makaleler
PDF Görüntüle
Dergi Bilgisi
Eseri Dinleyin
Alıntı Yap
Bu Sayfayı Yazdırın
Paylaş
Mendeley
