Özet:

This paper presents a case of chronic necrotizing pulmonary aspergillosis (CNPA) in a 61-yearold male patient with acute myeloid leukemia-M2 (AML-M2). The patient was admitted to our clinic with non-productive cough for eight months and hemoptysis for four months. He had been diagnosed with AML-M2 and treated with cytosine-arabinoside and idarubicin seven months earlier. Thorax computed tomography (CT) demonstrated bilateral, perivascular, and multiple small nodules as well as multiple thick wall cavitary lesions with irregular margins in the entire lung areas, especially the upper lobes. An open lung biopsy by thoracotomy was performed and mixed inflammatory cells, necrosis (without caseation), multinuclear giant cells, epitheloid histiocytes, and aspergillus hyphae with bronchial wall destruction were seen in biopsy specimens from the right upper lobe. The patient was treated with amphotericine B for three weeks. As a follow-up, itraconazole was administered for a year. The patient is the first case where CNPA along with an overt immune-compromising disease such as AML-M2 has been observed in one patient.

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