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Giriş ve Amaç: Helicobacter pylori geniş klinik ve endoskopik bir yelpaze ile karşımıza gelebilir. Çalışmamızda, Helicobacter pylori pozitif ve negatif hastalar arasındaki endoskopik ve patolojik farkları ortaya koymayı amaçladık. Gereç ve Yöntem: Çalışmamıza Helicobacter pylori pozitifliği saptanan 85 hasta ve Helicobacter pylori negatif 70 hasta alındı. Hastaların dosyaları retrospektif olarak analiz edildi. Bulgular: Helicobacter pylori pozitif hastaların yaş ortalaması 40.6 idi. Yaş aralığı 18 ve 77 arasında değişiyordu. Değerlendimeye alınan hastaların 42’si kadın idi. 61 hastada epigastrik ağrı şikayeti ön planda olup 11 hastada proton pompası inhibitörü tedavisine dirençli epigastrik ağrı şikayeti ön planda idi. Helicobacter pylori pozitif hastaların endoskopik görüntüleri analiz edildiğinde en sık olarak 31 hastada antral gastrit ve 15 hastada bulbus ülseri ön planda bulundu. 2 hastada komplet tip intestinal metaplazi, 3 hastada atrofik gastrit, 1 hastada erken dönem mide kanseri gözlendi. Helicobacter pylori negatif hastaların yaş ortalaması 43.7 olup 32 hasta kadındı. Bu hastalarda epigastrik ağrı şikayeti ön planda idi. Endoskopik değerlendirmede çoğunlukla antral gastrit ön planda iken, 5 hastada bulbusta ülser gözlendi, patolojik değerlendirmede 2 komplet metaplazi gözlenirken, atrofi ve kanser saptanmadı. Helicobacter pylori pozitif ve negatif hastalar arasında endoskopik ve patolojik bulgular arasında istatistiki fark saptanmadı. Sonuç: Endoskopik olarak prekanseröz yolakta yer alan, intestinal metaplazi, atrofik gastrit şüphelenilen hastalarda muhakkak Helicobacter pylori bakılmasını ve tedavi edilmesini öneriyoruz. Fakat prekanseröz olmayan durumlar için Helicobacter pylori negatif hastalarla, pozitif hastalar arasında istatistiki fark olmaması nedeniyle gelişmekte olan ülkelerde nasıl bir yol izlenmesi ile ilgili prospektif çalışmalara ihtiyaç vardır. , ,
Background and Aims: Helicobacter pylori may be detected with a wide range of clinical and endoscopic methods. In this study, we aimed to reveal the endoscopic and pathological differences between Helicobacter pylori positive (+) and negative (−) patients. Materials and Methods: We retrospectively analyzed the records of Helicobacter pylori (+) (n = 85, 42 women) and Helicobacter pylori (−) (n = 70, 32 women) patients the study. Results: The average age of Helicobacter pylori (+) patients was 40.6 years and their ages ranged from 18 to 77 years. Total 61 patients complained of epigastric pain, while 11 complained of epigastric pain resistant to PPI therapy. Endoscopic images of Helicobacter pylori (+) patients revealed that 31 patients presented with antral gastritis and 15 with bulb ulcers. Complete intestinal metaplasia was observed in two patients, atrophic gastritis in three patients, and early stage gastric cancer in one patient. Alternatively, the average age of Helicobacter pylori (−) patients was 43.7 years. These patients prominently complained of epigastric pain. Furthermore, most patients presented with antral gastritis in the endoscopic evaluation, while only five patients presented with bulb ulcers. There were two cases of complete metaplasia in the pathological evaluation, while no cases of atrophy or cancer were observed. The differences in the endoscopic and pathological findings Helicobacter pylori (+) and (−) patients were not statistically significant. Conclusion: We highly recommend studying and treating endoscopically detected Helicobacter pylori in the precancerous state,
Background and Aims: Helicobacter pylori may be detected with a wide range of clinical and endoscopic methods. In this study, we aimed to reveal the endoscopic and pathologic differences between Helicobacter pylori positive (+) and negative (−) patients. Materials and Methods: We retrospectively analyzed the records of Helicobacter pylori (+) (n = 85, 42 women) and Helicobacter pylori (−) (n = 70, 32 women) patients the study. Results: The mean age of Helicobacter pylori (+) patients was 40.6 years and their ages ranged from 18 to 77 years. Total 61 patients complained of epigastric pain, while 11 complained of epigastric pain resistant to PPI therapy. Endoscopic images of Helicobacter pylori (+) patients revealed that 31 patients presented with antral gastritis and 15 with bulb ulcers. Complete intestinal metaplasia was observed in two patients, atrophic gastritis in three patients, and early stage gastric cancer in one patient. Alternatively, mean age of Helicobacter pylori (−) patients was 43.7 years. These patients prominently complained of epigastric pain. Furthermore, most patients presented with antral gastritis in the endoscopic evaluation, while only five patients presented with bulb ulcers. There were two cases of complete metaplasia in the pathologic evaluation, while no cases of atrophy or cancer were observed. The differences in the endoscopic and pathologic findings Helicobacter pylori (+) and (−) patients were not statistically significant. Conclusion: We highly recommend studying and treating endoscopically detected Helicobacter pylori in the precancerous state, particularly in patients suspected of intestinal metaplasia and atrophic gastritis. However, prospective studies are needed to determine the necessary follow up measures for Helicobacter pylori (−) patients in developing countries owing to the absence of statistically significant differences with Helicobacter pylori (+) patients.
Field : Sağlık Bilimleri
Journal Type : Uluslararası
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