Abstract:

Objective: In this study, our aim was to investigate the relationship between iron deficiency anemia parameters and serum total sialic acid (SA) levels.   Methods: In this study, serum total SA levels, total blood count, iron levels, iron-binding capacity, ferritin levels, and C-reactive protein (CRP) levels were analyzed and peripheral blood smears were made for 30 patients with iron deficiency anemia and 30 healthy individuals. Statistical analyses were performed with SPSS 20.0 for Windows (Statistical Package for Social Sciences Inc., IL, USA). Independent t test and Pearson’s correlation analysis were performed for normal distribution parameters, and Mann–Whitney U test and Spearman correlation analysis were performed for abnormal distribution parameters.   Results: There was no significant age difference between the groups (p>0.05). In the patient group  hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and ferritin levels were found to be significantly lower (p<0.001) than the control group  and red cell distribution width (RDW) and SA levels were found to be significantly higher (p<0.001) than the control group.  CRP levels were not found to be significantly different between the patient and control groups. There was no correlation between CRP and SA levels (r=0.110, p=0.561).   Conclusion: Serum total SA levels were found higher in the patient group than in the control group. In previous studies, high SA levels in different patient groups have been associated with the presence of inflammation. Because there was no difference in CRP levels between the patient and control groups, this increase did not result from proteins, including SA, which is considered as an acute-phase reactant. 

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