Özet:

Purpose: In this study, it is planned to determine the relationship of cognitive functions with levels of serum nitric oxide (NO) and asymmetric dimetylary (ADMA) in patients diagnosed with bipolar disorder. Tools and Methods: Examples of the study were created from 45 healthy volunteers accompanied in terms of age, gender and training period with 45 patients in the period of eutymic diagnosed by the DSM-5, followed by the psychiatric clinic of the Afyon Kocatepe University School of Medicine. The participants were applied to the sociodemographic data form, Hamilton Depression Rating Scale and Young Mani Rating Scale. The neurocognitive functions were studied by the Test of Oral Memory Processes, the Wisconsin Card Combination Test, the Stroop Test and the Trace Running Test. Serum NO and ADMA levels were measured using ELISA kit. The findings: There was a significant difference (p=0,002) in the family psychiatric query between the two groups matched in terms of age, gender and educational status, and 31% of the patient group found bipolar disorder in the family. The patient group’s neuropsychological test results were statistically significantly lower than the control group. Serum ADMA levels were observed at a lower level than the control group in the patient group (p=0,001). The ADMA level and the self-memory score (p=0,037), the conceptual level reaction percentage (p=0,029), the Stroop test points (p=0,043) and the track run A test time (p=0,002) have a statistically meaningful relationship. Result: According to the results of this study, bipolar disorder patients have a disturbance in cognitive fields such as memory, learning, attention, process speed, change of strategy, problem solving but this disturbance is not related to the serum NO level, but it is determined that the memory itself, the percentage of conceptual reaction, the time of completion of the Stroop Test, the time of follow-up of the test points are related to ADMA.

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