Abstract:

This study has studied the effects of perylal alcohol on oxidative stress and apoptosis in the kidney tissue of diabetic rats. For this purpose, 40 rates were divided randomly into 4 groups equally. Group 1 (control) and 2. Group (Diabetes; STZ 50 mg/kg i.p, single dose), 3. Group (Perilyl Alcohol; Perilyl Alcohol 50 mg/kg/day p.o, 7 days), 4. Group (Diabetes + Peryl alcohol; STZ 50 mg/kg, single dose + Peryl alcohol 50 mg/kg/day, p.o. 7 days). At the end of the study, some biochemical parameters in kidney tissue samples were measured by Western blot analysis, the Bax and Bcl-2 levels, which are malondialdehitis (MDA), glutation (GSH), glutation peroxidase (GSH.Px), catalase (CAT) and apoptotic index markers. The study resulted in an increase in the MDA level in the group of diabetes created according to the control group (P<0. 01); the level of GSH, while the activity of GSH-Px and CAT has decreased (P<0.05). Compared to the Diabetes group, the MDA levels in the Diabetes+Peryl Alcohol group have decreased (P<0.01) and the GSH, GSH-Px and CAT activities have increased (P<0.05). The Bax protein levels increased according to the control group in the Diabetes group, but it decreased in the Diabetes+Peryl Alcohol group (P<0.05). The level of Bcl-2 has increased in the Diabetes+Peryl Alcohol group (P<0.05). Although the Bax/Bcl-2 rate has increased in the Diabetes group (P<0.05), it has decreased in the Diabetes+Peryl Alcohol group. As a result, it has been found that perylyl alcohol reduces oxidative stress that occurs in the early period of diabetes and increases antioxidant efficacy, while reducing the rate of Bax/Bcl-2, the apoptotic index.

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