Özet:

Purpose: Neural tube defects (NTDs) are the result of errors in the closure of the nerve tube in the embryos. The incidence of all forms of NTDs worldwide is between 1.4-2 in 1000 live births. Our study is aimed at assessing the factors that influence the NTD ethology. Method and means: Patients terminated due to the existence of NTD that is not compatible with life in the Düzce University Medical School of Women's Diseases and Birth Anabolics Department from May 2010 to May 2013 and patients treated with the diagnosis of NTD in the Düzce University Medical School of Children's Diseases Anabolics Department were included in this study. As a control group in Düzce Province, healthy single living baby births were taken. The study group has 30 patients and the control group has 30 patients. The difference between age, preconceptional/conceptional period folic acid replacement, previous pregnancy NTD history, occupation, co-profession, maternal education level, chronic disease history, smoking/alcohol use, preconceptional period and gestational body mass index (VKI) values has been compared. Results: Folic acid support given during pregnancy against the risk of NTD has been identified as an important protective factor (p=0.018). The increase in the mother’s educational level and the father’s profession are also other factors that influence the risk of NTD (p=0.012 and p=0.017). The result: New studies are needed in a widespread and random way to identify the factors affecting the risk of NTD in our country.

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