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Introduction: Ideal anaesthetic technique for middle ear surgeries is one which maintains hemodynamic stability , optimizes surgical field , minimizes coughing on emergence from anaesthesia and avoids postoperative nausea and vomiting. Aim of the study: To compare Hemodynamics (Heart rate , Systolic blood pressure , Diastolic blood pressure) and postoperative nausea and vomiting (PONV)in middle ear surgeries done under general anesthesia with Sevoflurane and Desflurane. Materials and Methods: After institutional ethics approval thestudy was conducted at Govt. ENT Hospital, Koti, Hyderabad ,Telangana state during 2016-2018. Study included patients in age group 12-60 years belonging to ASA I,II of both genders scheduled for elective middle ear surgeries under general anaesthesia, randomly divided into two equal groups-Group S (n-30) ,Group D(n-30) based on inhalation anaesthetic used. Intraoperatively hemodynamics were recorded at predetermined intervals, after extubation and recovery, postoperatively patients were transferred to post anesthesia care unit and incidence of ponv within first 23hrs were recorded. Results: Intraoperatively hemodynamics mean values between two groups were as Group S - Systolic, Diastolic blood pressure -118.85±9.72 and 77.01±6.93 (p value 0.481) , Group D - Systolic, Diastolic blood pressure-119.16±10.80 and 77.02±6.84 (p value 0.485) respectively, mean heart rates in Group S-86.00±12.09,Group D-84.75±11.50 (p value 0.337), incidence of ponv in Group S (23.33%) and Group D (26.66%). Intraoperative hemodynamics and incidence of postoperative nausea and vomiting between study groups were comparable and statistically insignificant. Conclusion: Sevoflurane and Desflurane showed no significant difference in intra operative hemodynamics and incidence of postoperative nausea and vomiting when used for anesthesia maintenance in middle ear surgeries.

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